ArticleCell host & microbe2012
SAMHD1 Joins the red Queen's court.
Article in Cell host & microbe, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.Retrovirology · 2014Article
- HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.The Journal of biological chemistry · 2013Article
- Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells.Viruses · 2012Review
- A cross-species view on viruses.Current opinion in virology · 2012Review
- Studies of endogenous retroviruses reveal a continuing evolutionary saga.Nature reviews. Microbiology · 2012Review
- MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.PLoS genetics · 2012Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The host restriction factor SAMHD1 hinders lentiviral infection of myeloid cells, a function counteracted by the viral protein Vpx. Two papers in this issue of Cell Host & Microbe document the genetic conflict between SAMHD1 and the Vpr/Vpx proteins, which has subjected SAMHD1 to intense periods of diversifying selection through primate evolution.
Identifiers
22341459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.