ArticleCell2012
Telomeres and cancer: from crisis to stability to crisis to stability.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer.Aging and disease · 2024Review
- The telomere maintenance mechanism spectrum and its dynamics in gliomas.Genome medicine · 2022Article
- APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.Nature genetics · 2020Article
- Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2019Review
- Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity.Scientific reports · 2019Article
- Integration of Telomere Length Dynamics into Systems Biology Framework: A Review.Gene regulation and systems biology · 2016Review
- TERT promoter mutations and telomere length in adult malignant gliomas and recurrences.Oncotarget · 2015Article
- Article
- Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.The Journal of pathology · 2014Article
- Evolving concepts of tumor heterogeneity.Cell & bioscience · 2014Review
- Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Telomere attrition unleashes genomic instability, promoting cancer development. Once established, however, the malignant clone often re-establishes genomic stability through overexpression of telomerase. In two papers, one in this issue of Cell and one in the subsequent issue, DePinho and colleagues explore the consequences of telomerase re-expression and its validity as a therapeutic target in mouse models of cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.