ArticleJACC. Cardiovascular imaging2012
Prediction of coronary artery calcium progression in individuals with low Framingham Risk Score: the Multi-Ethnic Study of Atherosclerosis.
Article in JACC. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The association between C-reactive protein and coronary artery calcification: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.JACC. Advances · 2026Article
- C-Reactive Protein-Triglyceride-Glucose Index and Coronary Artery Calcium Progression: A Prospective Cohort Analysis.Clinical cardiology · 2026Observational
- Opportunistic coronary calcium progression on routine chest CT improves cardiovascular risk stratification in patients with inflammatory bowel disease: a multicenter study.Frontiers in cardiovascular medicine · 2026Article
- Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study.European heart journal. Cardiovascular Imaging · 2025Article
- Long-term dual-trajectories of TyG and LAP and their association with cardiometabolic multimorbidity in midlife: the CARDIA study.Cardiovascular diabetology · 2025Article
- Novel plasma biomarkers of coronary artery calcium incidence or progression: Insights from the prospective multi-ethnic Dallas Heart Study cohort.Atherosclerosis · 2024Article
- Visceral adipose tissue is an independent predictor and mediator of the progression of coronary calcification: a prospective sub-analysis of the GEA study.Cardiovascular diabetology · 2023Article
- Association between coronary artery calcium and thoracic spine bone mineral density: Multiethnic Study of Atherosclerosis (MESA).Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function.Frontiers in endocrinology · 2023Article
- Prognostic Modelling Studies of Coronary Heart Disease-A Systematic Review of Conventional and Genetic Risk Factor Studies.Journal of cardiovascular development and disease · 2022Review
- Determinants of Incident Atherosclerotic Cardiovascular Disease Events Among Those With Absent Coronary Artery Calcium: Multi-Ethnic Study of Atherosclerosis.Circulation · 2022Article
- Association of dietary zinc intake with coronary artery calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA).European journal of nutrition · 2021Article
- Low-Carbohydrate Diet Score and Coronary Artery Calcium Progression: Results From the CARDIA Study.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases.Metabolic syndrome and related disorders · 2020Review
- Risk factors for progression of coronary artery calcification in patients with chronic kidney disease: The CRIC study.Atherosclerosis · 2018Article
- Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction.PloS one · 2018Article
- Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies.Oncotarget · 2017Article
- Aortic Calcification Onset and Progression: Association With the Development of Coronary Atherosclerosis.Journal of the American Heart Association · 2017Article
- Prediction of coronary artery calcium progression by FDG uptake of large arteries in asymptomatic individuals.European journal of nuclear medicine and molecular imaging · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesThis study sought to determine whether novel markers not involving ionizing radiation could predict coronary artery calcium (CAC) progression in a low-risk population.
backgroundIncrease in CAC scores over time (CAC progression) improves prediction of coronary heart disease (CHD) events. Due to radiation exposure, CAC measurement represents an undesirable method for repeated risk assessment, particularly in individuals with low predicted risk (Framingham Risk Score [FRS] <10%).
methodsFrom 6,814 participants in MESA (Multi-Ethnic Study of Atherosclerosis), 2,620 individuals were classified as low risk for CHD events (FRS <10%) and had follow-up CAC measurement. In addition to traditional risk factors (RFs), various combinations of novel marker models were selected on the basis of data-driven, clinical, or backward stepwise selection techniques.
resultsMean follow-up was 2.5 years. CAC progression occurred in 574 participants (22% overall; 214 of 1,830 with baseline CAC = 0 and 360 of 790 with baseline CAC >0). Addition of various combinations of novel markers to the base model (c statistic = 0.711) revealed improvements in discrimination of approximately only 0.005 each (c statistics 0.7158, 0.7160, and 0.7164) for the best-fit models. All 3 best-fit novel marker models calibrated well but were similar to the base model in predicting individual risk probabilities for CAC progression. The highest prevalence of CAC progression occurred in the highest compared with the lowest probability quartile groups (39.2% to 40.3% vs. 6.4% to 7.1%).
conclusionsIn individuals at low predicted risk according to FRS, traditional risk factors predicted CAC progression in the short term with good discrimination and calibration. Prediction improved minimally when various novel markers were added to the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.