ArticleEuropean journal of neurology2012
Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer's disease.
Article in European journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Associations among sleep-disordered breathing, arousal response, and risk of mild cognitive impairment in a northern Taiwan population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease.Journal of Parkinson's disease · 2022Article
- Artificial Neural Networks Analysis of polysomnographic and clinical features in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): from sleep alteration to "Brain Fog".Nature and science of sleep · 2021Article
- Analysis of Sleep Macrostructure in Patients Diagnosed with Parkinson's Disease.Behavioral sciences (Basel, Switzerland) · 2019Article
- Sleep Disorders Associated With Alzheimer's Disease: A Perspective.Frontiers in neuroscience · 2018Review
- Iron and restless legs syndrome: treatment, genetics and pathophysiology.Sleep medicine · 2017Article
- Article
- Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases.Current neurology and neuroscience reports · 2016Review
- Sleep correlates of trait executive function and memory in Parkinson's disease.Journal of Parkinson's disease · 2015Article
- Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer's disease using the Multiple Sleep Latency Test.Alzheimer's research & therapy · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeriodic leg movements in sleep (PLMS) are non-epileptiform, repetitive movements of the lower limbs that have been associated with apparent dopamine deficiency. We hypothesized that elderly patients with a disease characterized primarily by dopamine depletion (Parkinsonism) would have higher rates of PLMS than age-matched controls or a different neurodegenerative condition not primarily involving a hypodopaminergic state, Alzheimer's disease (AD).
methodsWe compared rates of PLMS derived from in-laboratory overnight polysomnography in patients with Parkinsonism (n = 79), AD (n = 28), and non-neurologically impaired, community-based controls (n = 187).
resultsPatients with Parkinsonism not receiving levodopa had significantly higher rates of PLMS than did patients with Parkinsonism receiving levodopa as well as higher rates than seen in AD and controls. Other medications did not appear to exert the pronounced effect of levodopa on PLMS in this Parkinsonian patient population. The symptom of leg kicking was reported more frequently in Parkinsonism and was associated with higher rates of PLMS. Caregiver reported leg kicking was unrelated to PLMS in AD.
conclusionsResults are broadly compatible with a dopaminergic hypothesis for PLMS in Parkinsonism. The clinical significance of the negative findings in patients with AD requires further investigation.
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