ArticleGenes, brain, and behavior2012
Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infants.
Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Regulation of emotional response in juvenile monkeys treated with fluoxetine: MAOA interactions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Peer social interaction is facilitated in juvenile rhesus monkeys treated with fluoxetine.Neuropharmacology · 2016Article
- Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys.The Journal of nutrition · 2015Article
- Sleep patterns in male juvenile monkeys are influenced by gestational iron deprivation and monoamine oxidase A genotype.The British journal of nutrition · 2014Article
- Fluoxetine: juvenile pharmacokinetics in a nonhuman primate model.Psychopharmacology · 2014Article
- Developmental plasticity of red blood cell homeostasis.American journal of hematology · 2014Article
- Prenatal iron deficiency and monoamine oxidase A (MAOA) polymorphisms: combined risk for later cognitive performance in rhesus monkeys.Genes & nutrition · 2014Article
- Effect of dietary iron on fetal growth in pregnant mice.Comparative medicine · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Social and emotional behaviors are known to be sensitive to both developmental iron deficiency (ID) and monoamine oxidase A (MAOA) gene polymorphisms. In this study, male rhesus monkey infants deprived of dietary iron in utero were compared with iron sufficient (IS) controls (n = 10/group). Half of each group had low MAOA activity genotypes and half had high MAOA activity genotypes. A series of social response tests were conducted at 3-14 months of age. MAOA genotype influenced attention to a video of aggressive behavior, emotional expression (fear, grimace and sniff) in the social intruder test, social actions (displacement, grooming) in the social dyad test, and aggressive responses to a threatening picture. Interactions between MAOA and prenatal ID were seen in response to the aggressive video, in temperament ratings, in affiliative behavior in the social dyad test, in cortisol response in the social buffering test and in response to a social intruder and to pictures with social and nonsocial themes. In general, the effects of ID were dependent on MAOA genotype in terms of both direction and size of the effect. Nutrition/genotype interactions may shed new light on behavioral consequences of nutritional deprivation during brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.