Evidence map›Paper›PMID 22340204›Full record

ReviewMicrocirculation (New York, N.Y. : 1994)2012

Intercellular communication in the vascular wall: a modeling perspective.

Sridevi Nagaraja, Adam Kapela, Nikolaos M Tsoukias

Abstract readReview
In one paragraph

Review in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. AlphaPhysiological reports · 2018
    Article
  4. Can endothelial hemoglobin-α regulate nitric oxide vasodilatory signaling?American journal of physiology. Heart and circulatory physiology · 2017
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sridevi NagarajaDepartment of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA.
Adam Kapela
Nikolaos M Tsoukias

Funding

Theorectal and Experimental Investigations of Microcirculatory SignalingSC1HL095101 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2008 to 2012
$1.4M
NHLBI NIH HHS SC1 HL095101NHLBI NIH HHS SC1HL95101
6 · The paper itself

Abstract

Movement of ions (Ca(2+) , K(+) , Na(+) , and Cl(-) ) and second messenger molecules like inositol 1, 4, 5-trisphosphate inside and in between different cells is the basis of many signaling mechanisms in the microcirculation. In spite of the vast experimental efforts directed toward evaluation of these fluxes, it has been a challenge to establish their roles in many essential microcirculatory phenomena. Recently, detailed theoretical models of calcium dynamics and plasma membrane electrophysiology have emerged to assist in the quantification of these intra and intercellular fluxes and enhance understanding of their physiological importance. This perspective reviews selected models relevant to estimation of such intra and intercellular ionic and second messenger fluxes and prediction of their relative significance to a variety of vascular phenomena, such as myoendothelial feedback, conducted responses, and vasomotion.

Indexed as

Models, CardiovascularAnimalsCell CommunicationEndothelium, VascularHemodynamicsHumansIonsIon TransportMuscle, Smooth, VascularSecond Messenger SystemsIons

Identifiers

PMID22340204
PMCPMC4393014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.