ArticleJournal of the American Chemical Society2012
Growth rates of protein crystals.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation.IUCrJ · 2026Article
- A multiscaleJournal of applied crystallography · 2025Article
- Competing addition processes give distinct growth regimes in the assembly of 1D filaments.Biophysical journal · 2025Article
- Beneficial and detrimental effects of non-specific binding during DNA hybridization.Biophysical journal · 2023Article
- Not getting in too deep: A practical deep learning approach to routine crystallisation image classification.PloS one · 2023Article
- Unraveling the Impact of pH on the Crystallization of Pharmaceutical Proteins: A Case Study of Human Insulin.Crystal growth & design · 2022Article
- Catalystlike role of impurities in speeding layer-by-layer growth.Physical review. E · 2019Article
- The "speed limit" for macromolecular crystal growth.Protein science : a publication of the Protein Society · 2018Article
- Theory of Sequence Effects in Amyloid Aggregation.The journal of physical chemistry. B · 2018Article
- Minimal physical requirements for crystal growth self-poisoning.The Journal of chemical physics · 2016Article
- Article
- Characterizing protein crystal contacts and their role in crystallization: rubredoxin as a case study.Soft matter · 2014Article
- A strategy for selecting the pH of protein solutions to enhance crystallization.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- An investigation of the effects of self-assembled monolayers on protein crystallisation.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Protein crystallization is important for structural biology. The rate at which a protein crystallizes is often the bottleneck in determining the protein's structure. Here, we give a physical model for the growth rates of protein crystals. Most materials crystallize faster under stronger growth conditions; however, protein crystallization slows down under the strongest conditions. Proteins require a crystallization slot of 'just right' conditions. Our model provides an explanation. Unlike simpler materials, proteins are orientationally asymmetrical. Under strong conditions, protein molecules attempt to crystallize too quickly, in wrong orientations, blocking surface sites for more productive crystal growth. The model explains the observation that increasing the net charge on a protein increases the crystal growth rate. The model predictions are in good agreement with experiments on the growth rates of tetragonal lysozyme crystals as a function of pH, salt concentration, temperature, and protein concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.