ArticleJournal of child psychology and psychiatry, and allied disciplines2012
Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Artificial intelligence applications in psychoradiology.Psychoradiology · 2021Article
- The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder.BMC psychiatry · 2021Article
- Neuropsychology of Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study.Bipolar disorders · 2015Article
- Distinguishing bipolar disorder from other psychiatric disorders in children.Current psychiatry reports · 2014Review
- Negative emotion impairs working memory in pediatric patients with bipolar disorder type I.Psychological medicine · 2012Article
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Authors and funding
5 authors.
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Abstract
backgroundImpaired profiles of neurocognitive function have been consistently demonstrated among pediatric patients with bipolar disorder (BD), and may aid in the identification of endophenotypes across subtypes of the disorder. This study aims to determine phenotypic cognitive profiles of patients with BD Type I and II.
methodsSubjects (N = 79) consisted of BD I (n = 27) and BD II (n = 19) patients and demographic and intellectually matched healthy controls (HC; n = 33) that completed a battery of neurocognitive tasks.
resultsBipolar disorder Type I patients performed significantly more poorly compared to HC on all domains of cognitive function including attention, executive function, working memory, visual memory, and verbal learning and memory. BD I patients also performed more poorly compared to BD II patients on all domains of cognitive functioning with the exception of working memory, whereas BD II patients did poorly relative to HC only on verbal learning and memory.
conclusionsFindings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients.
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