Evidence map›Paper›PMID 22338612›Full record

ArticleClimacteric : the journal of the International Menopause Society2012

Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging.

Siobán D Harlow, Margery Gass, Janet E Hall, Roger Lobo, Pauline Maki, Robert W Rebar, Sherry Sherman, Patrick M Sluss, Tobie J de Villiers, STRAW+10 Collaborative Group

Open access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Climacteric : the journal of the International Menopause Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 8 pooled it
36.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 8 syntheses or guidelines pooled it, 775 citations in OpenAlex.

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  6. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2015
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  18. Effects ofNutrients · 2022
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Siobán D HarlowDepartment of Epidemiology, University of Michigan 1415 Washington Heights, Ann Arbor, MI 48109, USA. harlow@umich.edu
Margery Gass
Janet E Hall
Roger Lobo
Pauline Maki
Robert W Rebar
Sherry Sherman
Patrick M Sluss
Tobie J de Villiers
STRAW+10 Collaborative Group
North American Menopause Society · USAmerican Society for Reproductive Medicine · USBeijing Obstetrics and Gynecology Hospital · CNColumbia University · USEndocrine Society · USHarvard University · USIllinois College · USInstitute of Aging · CA

Funding

Population Studies Center Infrastructure GrantR24HD041028 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMOCK, PAMELA J. · 2001 to 2016
$13.2M
STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBMR13AG039961 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2011 to 2011
$54k
NIA NIH HHS AG039961NIA NIH HHS R13 AG039961NICHD NIH HHS R24 HD041028
6 · The paper itself

Abstract

objectiveThe aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW +10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period.

methodsScientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus.

resultsSTRAW +10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics.

conclusionsSTRAW +10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW +10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.

Indexed as

AgedAged, 80 and overAgingAnti-Mullerian HormoneBiomarkersBiomedical ResearchEndometrial Ablation TechniquesFemaleFollicle Stimulating Hormone, HumanHumansHypothalamo-Hypophyseal SystemHysterectomyInhibinsMenopauseMenstrual CycleMiddle AgedAnti-Mullerian HormoneBiomarkersFollicle Stimulating Hormone, Humaninhibin BInhibins

Identifiers

PMID22338612
PMCPMC3580996
OpenAlexW2787895246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.