ArticleDiabetes care2012
Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Impact of low-density lipoprotein cholesterol on cardiovascular outcomes in people with type 2 diabetes: a meta-analysis of prospective cohort studies.Diabetes research and clinical practice · 2013Pooled it
- The role of triglyceride in cardiovascular disease in asian patients with type 2 diabetes--a systematic review.The review of diabetic studies : RDSPooled it
- Japan Diabetes Complications Study: Revisiting one of the first large-scale clinical studies in East Asians with diabetes.Journal of diabetes investigation · 2025Review
- Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis.Communications medicine · 2024Article
- Predictive effect of different blood lipid parameters combined with carotid intima-media thickness on coronary artery disease.Frontiers in cardiovascular medicine · 2022Article
- Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population.Cardiovascular diabetology · 2021Article
- An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort.Scientific reports · 2021Article
- Effect of postprandial hyperglycemia at clinic visits on the incidence of retinopathy in patients with type 2 diabetes: An analysis using real-world long-term follow-up data.Journal of diabetes investigation · 2020Article
- Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women.The Proceedings of the Nutrition Society · 2020Review
- Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes.Journal of family medicine and primary care · 2020Article
- The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus.Journal of atherosclerosis and thrombosis · 2019Observational
- Comparison of various lipid parameters in association of target organ damage: a cohort study.Lipids in health and disease · 2018Article
- Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus.Annals of vascular diseases · 2018Review
- Article
- Impact of postprandial hyperglycemia at clinic visits on the incidence of cardiovascular events and all-cause mortality in patients with type 2 diabetes.Journal of diabetes investigation · 2017Observational
- Genetics of cardiovascular and renal complications in diabetes.Journal of diabetes investigation · 2016Review
- Is the ratio of apoB/apoA-1 the best predictor for the severity of coronary artery lesions in Chinese diabetics with stable angina pectoris? An assessment based on Gensini scores.Journal of geriatric cardiology : JGC · 2015Article
- The combined effect of visit-to-visit variability in HbA1c and systolic blood pressure on the incidence of cardiovascular events in patients with type 2 diabetes.BMJ open diabetes research & care · 2015Article
- Cohort profile: The Japan diabetes complications study: a long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes.International journal of epidemiology · 2014Article
Corrections and comments
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the best lipid variable to predict coronary heart disease (CHD) in Japanese patients with type 2 diabetes. RESEARCH DESIGN AND
methodsEligible Japanese men and women (1,771) aged 40-70 years with type 2 diabetes from 59 institutes nationwide were followed for a planned 8-year period. The performance of eight conventional lipid variables, i.e., total cholesterol (TC), LDL-cholesterol (LDLC), HDL-cholesterol (HDLC), triglycerides (TGs), non-HDLC, TC/HDLC ratio, LDLC/HDLC ratio, and TG/HDLC ratio, as predictors of incident CHD were evaluated by four methods: hazard ratio (HR) per one SD increment by multivariate Cox analysis, χ(2) likelihood ratio test, area under the receiver operating characteristic curve (AUC), and tertile analysis.
resultsAlthough all variables significantly predicted CHD events in men, non-HDLC (HR per one SD 1.78 [95% CI 1.43-2.21]; AUC 0.726) and TC/HDLC (HR 1.63 [1.36-1.95]; AUC 0.718) had the better predictive performances among the variables, including LDLC. In women, TGs (log-transformed; HR 1.72 [1.21-2.43]; AUC 0.708) were the best predictor according to results of tertile analysis (HR of the top tertile versus the bottom tertile 4.31 [1.53-12.16]). The associations with incident CHD were linear and continuous.
conclusionsFor Japanese diabetic men, non-HDLC and TC/HDLC were the best predictors, whereas TGs were most predictive for women. These findings, which included prominent sex differences, should be considered among clinical approaches to risk reduction among East Asians with diabetes.
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