Evidence map›Paper›PMID 22338051›Full record

ArticleAmerican journal of clinical pathology2012

Clinical and pathologic features of secondary acute promyelocytic leukemia.

Amy S Duffield, Joseph Aoki, Mark Levis, Kathleen Cowan, Christopher D Gocke, Kathleen H Burns, Michael J Borowitz, Milena Vuica-Ross

Abstract readComparative Study
In one paragraph

Article in American journal of clinical pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Therapy-related acute promyelocytic leukemia: a systematic review.Medical oncology (Northwood, London, England) · 2013
    Pooled it
  2. Article
  3. Review
  4. Full spectrum flow cytometry in the clinical laboratory.International journal of laboratory hematology · 2023
    Review
  5. Article
  6. Optimizing outcomes in secondary AML.Hematology. American Society of Hematology. Education Program · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy S DuffieldDepartment of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Joseph Aoki
Mark Levis
Kathleen Cowan
Christopher D Gocke
Kathleen H Burns
Michael J Borowitz
Milena Vuica-Ross

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases of APL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms.

Indexed as

AdolescentAdultAgedAged, 80 and overAntigens, CDBiomarkers, TumorBone Marrow CellsChromosome AberrationsCombined Modality TherapyFemaleFlow CytometryGranulocyte Precursor CellsHumansImmunocompromised HostImmunophenotypingLeukemia, Myeloid, AcuteAntigens, CDBiomarkers, TumorProtein-Tyrosine Kinases

Identifiers

PMID22338051
PMCPMC3578661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.