ArticleThe Journal of biological chemistry2012
Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Rac1 in gastric cancer: a molecular driver of invasion, EMT, and therapeutic resistance.Journal of translational medicine · 2025Review
- P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease.Neurobiology of disease · 2023Article
- The Impact of Different Cell Culture Mediums on CD8+ T Cells Expansion: A Bioinformatics Study.Cell journal · 2022Article
- The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2XInternational journal of molecular sciences · 2021Article
- Review
- Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells.Small GTPases · 2021Review
- Chemical individuality in T cells: A Garrodian view of immunometabolism.Immunological reviews · 2020Review
- McArdle Disease: New Insights into Its Underlying Molecular Mechanisms.International journal of molecular sciences · 2019Review
- Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family.The Journal of biological chemistry · 2019Article
- Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.Cell metabolism · 2019Article
- The regulation of glycogenolysis in the brain.The Journal of biological chemistry · 2018Review
- Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease.Aging cell · 2016Article
- Taking advantage of an old concept, "illegitimate transcription", for a proposed novel method of genetic diagnosis of McArdle disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes.Molecular & cellular proteomics : MCP · 2016Article
- Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.The Journal of biological chemistry · 2015Article
- Detecting glycogen in peripheral blood mononuclear cells with periodic acid schiff staining.Journal of visualized experiments : JoVE · 2014Article
- Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage.Molecular endocrinology (Baltimore, Md.) · 2013Article
- 1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small GTPases of the Rho family have been implicated in important cellular processes such as cell migration and adhesion, protein secretion, and/or gene transcription. In the lymphoid system, these GTPases participate in the signaling cascades that are activated after engagement of antigen receptors. However, little is known about the role that Rho GTPases play in IL-2-mediated responses. Here, we show that IL-2 induces Rac1 activation in Kit 225 T cells. We identified by mass spectrometry the muscle isoform of glycogen phosphorylase (PYGM) as a novel Rac1 effector molecule in IL-2-stimulated cells. The interaction between the active form of Rac1 (Rac1-GTP) and PYGM was established directly through a domain comprising amino acids 191-270 of PYGM that exhibits significant homology with the Rac binding domain of PAK1. The integrity of this region was crucial for PYGM activation. Importantly, IL-2-dependent cellular proliferation was inhibited upon blocking both the activation of Rac1 and the activity of PYGM. These results reveal a new role for Rac1 in cell signaling, showing that this GTPase triggers T cell proliferation upon IL-2 stimulation by associating with PYGM and modulating its enzymatic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.