ArticleEuropean journal of pain (London, England)2012
Diverse sensory inputs permit priming in the acidic saline model of hyperalgesia.
Article in European journal of pain (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain.PNAS nexus · 2024Article
- Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.Scientific reports · 2022Article
- Resident Macrophages in Muscle Contribute to Development of Hyperalgesia in a Mouse Model of Noninflammatory Muscle Pain.The journal of pain · 2016Article
- Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Animal models of fibromyalgia.Arthritis research & therapy · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe rodent acidic saline model of hyperalgesia uses repeat injections of acidic saline in the right lateral gastrocnemius muscle, spaced five days apart, to induce a persistent decrease in hindpaw withdrawal thresholds. The objective of this study was to determine if alternate injection sites would permit development of hyperalgesia.
methodsThe location of the first muscle injection was varied between 3 groups of rats to include the right lateral gastrocnemius, the right medial gastrocnemius or the left lateral gastrocnemius. All second injections were placed in the right lateral gastrocnemius.
resultsAs reported by others, placing both injections in the right lateral gastrocnemius produced a significant reduction in paw withdrawal thresholds 24 hours after the second injection (p < 0.05). Relocating the first injection to the right medial gastrocnemius or the left lateral gastrocnemius also produced significant reductions in paw withdrawal thresholds (p < 0.05 for both). Hyperalgesia was also observed if the first muscle injection was replaced with a systemic injection of lipopolysaccharide. Further experiments tested whether glia cells may contribute to the priming process. Pretreatment with minocycline prior to the first injection completely blocked the development of hyperalgesia but was ineffective if injected before the second injection.
conclusionsThese data indicate that anatomically diverse peripheral stimuli can converge within the central nervous system to produce hyperalgesia.
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Registered trials
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