Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012
Validity of eight integrated healthcare delivery organizations' administrative clinical data to capture breast cancer chemotherapy exposure.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Association of systemic therapy with survival among adults with advanced non-small cell lung cancer.Translational lung cancer research · 2025Article
- Representativeness of Patients With Lung Cancer in an Integrated Health Care Delivery System.The Permanente journal · 2024Observational
- Uptake of novel systemic therapy: Real world patterns among adults with advanced non-small cell lung cancer.Cancer treatment and research communications · 2023Article
- Validity of Administrative Databases in Comparison to Medical Charts for Breast Cancer Treatment Data.Journal of cancer epidemiology · 2018Article
- Algorithm to Identify Systemic Cancer Therapy Treatment Using Structured Electronic Data.JCO clinical cancer informatics · 2017Article
- Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer.Clinical lung cancer · 2017Article
- Comparison of SEER Treatment Data With Medicare Claims.Medical care · 2016Article
- Validation of Test Performance and Clinical Time Zero for an Electronic Health Record Embedded Severe Sepsis Alert.Applied clinical informatics · 2016Article
- Developing an Algorithm to Identify History of Cancer Using Electronic Medical Records.EGEMS (Washington, DC) · 2016Article
- Representativeness of breast cancer cases in an integrated health care delivery system.BMC cancer · 2015Article
- Treatment patterns for ductal carcinoma in situ from 2000-2010 across six integrated health plans.SpringerPlus · 2015Article
- Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2014Article
- Comparative effectiveness of adjunctive bevacizumab for advanced lung cancer: the cancer research network experience.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Article
- The HMO Research Network Virtual Data Warehouse: A Public Data Model to Support Collaboration.EGEMS (Washington, DC) · 2014Article
- Diffusion of Intraperitoneal Chemotherapy in Women with Advanced Ovarian Cancer in Community Settings 2003-2008: The Effect of the NCI Clinical Recommendation.Frontiers in oncology · 2014Article
- Cancer research network: using integrated healthcare delivery systems as platforms for cancer survivorship research.Journal of cancer survivorship : research and practice · 2013Review
- Patterns and predictors of breast cancer chemotherapy use in Kaiser Permanente Northern California, 2004-2007.Breast cancer research and treatment · 2013Article
- Patterns and predictors of first-line chemotherapy use among adults with advanced non-small cell lung cancer in the cancer research network.Lung cancer (Amsterdam, Netherlands) · 2012Article
- Utilization of HER2 genetic testing in a multi-institutional observational study.The American journal of managed care · 2012Article
- Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study.Journal of the National Cancer Institute · 2012Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundCancer Research Network (CRN) sites use administrative data to populate their Virtual Data Warehouse (VDW). However, information on VDW chemotherapy data validity is limited. The purpose of this study was to assess the validity of VDW chemotherapy data.
methodsThis was a retrospective cohort study of women ≥18 years with incident, invasive breast cancer diagnosed between January 1999 and December 2007. Pharmacy and procedure chemotherapy data were extracted from each site's VDW. Random samples of 50 patients stratified on trastuzumab, anthracyclines, and no chemotherapy exposure was selected from each site for detailed chart abstraction. Weighted sensitivities and specificities of VDW compared with abstracted data were calculated. Cumulative doses calculated from VDW data were compared with doses obtained from the medical chart review.
resultsThe cohort included 13,497 patients with 6,456 (48%) chart review eligible. Patients in the sample (N = 400) had a mean age of 65 years. Trastuzumab, anthracycline, and other chemotherapy weighted sensitivities were 95%, 97%, and 100%, respectively; specificities were 99%, 99%, and 93%, respectively; positive predictive values were 96%, 99%, and 55%, respectively; and negative predictive values were 99%, 96%, and 100%. Trastuzumab and anthracyclines VDW mean doses were 873 and 386 mg, respectively, whereas abstracted mean doses were 1,734 and 369 mgs, respectively (R(2) = 0.14, P < 0.01 and R(2) = 0.05, P = 0.03, respectively).
conclusionsSensitivities and specificities for CRN chemotherapy VDW data were high and dosages were correlated with chart information. IMPACT: The findings support the use of CRN data in evaluating chemotherapy exposures and related outcomes.
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