ArticleJournal of speech, language, and hearing research : JSLHR2012
Myosin heavy chain composition of the human genioglossus muscle.
Article in Journal of speech, language, and hearing research : JSLHR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluating the Association Between Risk Factors of Obstructive Sleep Apnea with Oral Dysfunction and Lifestyle Behavior in Korean Adults Using Data from the Eighth Cycle of the National Health and Nutrition Examination Survey: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.eLife · 2023Article
- Tongue Strength in Children With and Without Speech Sound Disorders.American journal of speech-language pathology · 2019Article
- Influence of respiratory mechanics and drive on genioglossus movement under ultrasound imaging.PloS one · 2018Article
- Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus.Experimental gerontology · 2016Article
- Nonspeech Oral Movements and Oral Motor Disorders: A Narrative Review.American journal of speech-language pathology · 2015Review
- A comprehensive assessment of genioglossus electromyographic activity in healthy adults.Journal of neurophysiology · 2015Article
- Absence of developmental and unconventional myosin heavy chain in human suprahyoid muscles.Muscle & nerve · 2014Article
- A new de novo missense mutation in MYH2 expands clinical and genetic findings in hereditary myosin myopathies.Neuromuscular disorders : NMD · 2013Article
- Differential effects of targeted tongue exercise and treadmill running on aging tongue muscle structure and contractile properties.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Functional role of neural injury in obstructive sleep apnea.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe human tongue muscle genioglossus (GG) is active in speech, swallowing, respiration, and oral transport, behaviors encompassing a wide range of tongue shapes and movement speeds. Studies demonstrate substantial diversity in patterns of human GG motor unit activation, but whether this is accompanied by complex expression of muscle contractile proteins is not known. PURPOSE: The authors tested for conventional myosin heavy chain (MHC) MHCI, MHCIIA, MHCIIX, developmental MHCembryonic and MHCneonatal and unconventional MHCαcardiac, MHCextraocular, and MHCslow tonic in antero-superior (GG-A) and posterior (GG-P) adult human GG.
methodSDS-PAGE, Western blot, and immunohistochemistry were used to describe MHC composition of GG-A and GG-P and the prevalence of muscle fiber MHC phenotypes in GG-A.
resultsBy SDS-PAGE, only conventional MHC are present with ranking from most to least prevalent MHCIIA > MHCI > MHCIIX in GG-A and MHCI > MHCIIA > MHCIIX in GG-P. By immunohistochemistry, many muscle fibers contain MHCI, MHCIIA, and MHCIIX, but few contain developmental or unconventional MHC. GG-A is composed of 5 phenotypes (MHCIIA > MHCI-IIX > MHCI > MHCI-IIA > MHCIIX). Phenotypes MHCI, MHCIIA, and MHCI-IIX account for 96% of muscle fibers.
conclusionsDespite activation of GG during kinematically diverse behaviors and complex patterns of GG motor unit activity, the human GG is composed of conventional MHC isoforms and 3 primary MHC phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.