ArticleMolecular and cellular biology1990
Structure and evolution of the U2 small nuclear RNA multigene family in primates: gene amplification under natural selection?
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Structure and Organization of the Engraulidae Family U2 snRNA: An Evolutionary Model Gene?Journal of molecular evolution · 2015Article
- Developmental analysis of spliceosomal snRNA isoform expression.G3 (Bethesda, Md.) · 2014Article
- Genetic characterization of Plectorhinchus mediterraneus yields important clues about genome organization and evolution of multigene families.BMC genetics · 2012Article
- snRNA 3' end formation: the dawn of the Integrator complex.Biochemical Society transactions · 2010Review
- Article
- Human U2 snRNA genes exhibit a persistently open transcriptional state and promoter disassembly at metaphase.Molecular and cellular biology · 2008Article
- Concerted evolution: molecular mechanism and biological implications.American journal of human genetics · 1999Review
- The microsatellite sequence (CT)n x (GA)n promotes stable chromosomal integration of large tandem arrays of functional human U2 small nuclear RNA genes.Molecular and cellular biology · 1998Article
- Human genes encoding U3 snRNA associate with coiled bodies in interphase cells and are clustered on chromosome 17p11.2 in a complex inverted repeat structure.Nucleic acids research · 1997Article
- Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion.The EMBO journal · 1997Article
- Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.The EMBO journal · 1995Article
- Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome.Molecular and cellular biology · 1993Article
- The distribution and spreading of rare variants in the histone multigene family of Drosophila melanogaster.Genetics · 1993Article
- Differential expression of U5snRNA gene variants in maize (Zea mays) protoplasts.Plant molecular biology · 1993Article
- Evolution of the master Alu gene(s).Journal of molecular evolution · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The organization of U2 genes was compared in apes, Old World monkeys, and the prosimian galago. In humans and all apes (gibbon, orangutan, gorilla, and chimpanzee), the U2 genes were organized as a tandem repeat of a 6-kb element; however, the restriction maps of the 6-kb elements in these divergent species differed slightly, demonstrating that mechanisms must exist for maintaining sequence homogeneity within this tandem array. In Old World monkeys, the U2 genes were organized as a tandem repeat of an 11-kb element; the restriction maps of the 11-kb elements in baboon and two closely related macaques, bonnet and rhesus monkeys, also differed slightly, confirming that efficient sequence homogenization is an intrinsic property of the U2 tandem array. Interestingly, the 11-kb monkey repeat unit differed from the 6-kb hominid repeat unit by a 5-kb block of monkey-specific sequence. Finally, we found that the U2 genes of the prosimian galago were dispersed rather than tandemly repeated, suggesting that the hominid and Old World monkey U2 tandem arrays resulted from independent amplifications of a common ancestral U2 gene. Alternatively, the 5-kb monkey-specific sequence could have been inserted into the 6-kb array or deleted from the 11-kb array soon after divergence of the hominid and Old World monkey lineages.
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