ArticleAmerican journal of hypertension2012
Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function.
Article in American journal of hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Low-Fat Diet Designed for Weight Loss But Not Weight Maintenance Improves Nitric Oxide-Dependent Arteriolar Vasodilation in Obese Adults.Nutrients · 2019Trial
- Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease.Circulation research · 2018Trial
- Reduced flow-and acetylcholine-induced dilations in visceral compared to subcutaneous adipose arterioles in human morbid obesity.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system.Reviews in endocrine & metabolic disorders · 2025Review
- Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications.Cardiovascular diabetology · 2021Article
- Tetrahydrobiopterin Restores Microvascular Dysfunction in Young Adult Binge Drinkers.Alcoholism, clinical and experimental research · 2020Article
- Overview of the Assessment of Endothelial Function in Humans.Frontiers in medicine · 2020Review
- Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation.Cardiovascular diabetology · 2019Article
- Aging women and their endothelium: probing the relative role of estrogen on vasodilator function.American journal of physiology. Heart and circulatory physiology · 2019Review
- Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.Journal of the American Heart Association · 2019Article
- Flow-mediated dilation and heart failure: a review with implications to physical rehabilitation.Heart failure reviews · 2019Review
- miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders.EMBO molecular medicine · 2018Article
- Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy.Journal of visualized experiments : JoVE · 2017Article
- Short-term regular aerobic exercise reduces oxidative stress produced by acute in the adipose microvasculature.American journal of physiology. Heart and circulatory physiology · 2017Article
- Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles.American journal of physiology. Heart and circulatory physiology · 2017Article
- WNT5A-JNK regulation of vascular insulin resistance in human obesity.Vascular medicine (London, England) · 2016Article
- Monosialoganglioside-Containing Nanoliposomes Restore Endothelial Function Impaired by AL Amyloidosis Light Chain Proteins.Journal of the American Heart Association · 2016Article
- Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.Circulation research · 2016Review
- Short-term high salt intake reduces brachial artery and microvascular function in the absence of changes in blood pressure.Journal of hypertension · 2016Article
- The Human Microcirculation: Regulation of Flow and Beyond.Circulation research · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNoninvasive measurements of endothelial function predict future adverse cardiovascular events, but offer limited opportunities for mechanistic insights into phenotypic observations. Subcutaneous adipose arterioles, accessible through minimally invasive methods, provide an opportunity for complimentary mechanistic studies. Limited data relating subcutaneous arteriolar endothelial function, cardiovascular risk factors, and noninvasive measurements of endothelial function currently exist.
methodsForty-four subjects underwent noninvasive studies of endothelial function (brachial reactivity (flow-mediated dilation (FMD) and digital pulse arterial tonometry (PAT)) and measurements of endothelial-dependent vasodilation of gluteal subcutaneous arterioles to acetylcholine. Arteriolar endothelial function was measured (i) percent vasodilation to maximal acetylcholine dose (10(-5) mol/l) and (ii) total area under the curve (AUC) for the entire acetylcholine dose-response curve (total AUC-acetylcholine (Ach), doses 10(-10)-10(-5) mol/l).
resultsAcetylcholine responses were almost completely nitric oxide (NO) dependent. Total AUC-Ach predicted FMD and PAT, but maximal acetylcholine vasodilation was not associated with these measures. A history of hypertension, diabetes, smoking, and low-density lipoprotein cholesterol levels were independent predictors of total AUC-Ach. In regression models, total AUC-Ach independently predicted FMD.
conclusionsAcetylcholine vasodilator responses in human gluteal subcutaneous arterioles are NO synthase dependent and correlate with cardiac risk factors and in vivo measures of endothelial function. These data suggest subcutaneous arterioles offer an opportunity for translational studies of mechanisms of modulating NO bioavailability relevant to in vivo endothelial function measures.
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