Trial reportEuropean journal of pain (London, England)2012
What do plasma beta-endorphin levels reveal about endogenous opioid analgesic function?
Trial report in European journal of pain (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Endogenous opioid antagonism in physiological experimental pain models: a systematic review.PloS one · 2015Pooled it
- Do Resting Plasma β-Endorphin Levels Predict Responses to Opioid Analgesics?The Clinical journal of pain · 2017Trial
- Can therapy dogs improve pain and satisfaction after total joint arthroplasty? A randomized controlled trial.Clinical orthopaedics and related research · 2015Trial
- Prospective evaluation of cerebrospinal fluid concentrations of β-Endorphin as a predictor of opioid use after scheduled cesarean delivery.BMC pregnancy and childbirth · 2025Article
- Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling.Veterinary world · 2025Article
- Behavioral, physiological, and hormonal responses during pre-slaughter handling in goats: a comparison between trained and untrained handlers.Animal bioscience · 2024Article
- Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery.The journal of pain · 2024Article
- The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024Review
- Investigating the impact of preslaughter handling intensity on goats: a study on behavior, physiology, blood enzymes, and hormonal responses.Frontiers in veterinary science · 2024Article
- Chronic pain in the elderly: Exploring cellular and molecular mechanisms and therapeutic perspectives.Frontiers in aging · 2024Review
- Pain, Fear, Anxiety, and Stress: Relations to the Endogenous Opioid System.Advances in neurobiology · 2024Article
- Endogenous Opioids and Exercise-Related Hypoalgesia: Modern Models, Measurement, and Mechanisms of Action.Advances in neurobiology · 2024Article
- Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors.Biomedicines · 2022Review
- Neuroendocrine effects of a single bout of functional and core stabilization training in women with chronic nonspecific low back pain: A crossover study.Physiological reports · 2022Article
- Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Endogenous opioid systems alterations in pain and opioid use disorder.Frontiers in systems neuroscience · 2022Review
- Chronic Pain in the Elderly: Mechanisms and Distinctive Features.Biomolecules · 2021Review
- Beta-Endorphin as a Biomarker in the Treatment of Chronic Pain with Non-Invasive Brain Stimulation: A Systematic Scoping Review.Journal of pain research · 2021Article
- Laser Analgesia Associated with Restorative Dental Care: A Systematic Review of the Rationale, Techniques, and Energy Dose Considerations.Dentistry journal · 2020Review
- Examination of pain threshold and neuropeptides in patients with acute suicide risk.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Plasma levels of beta-endorphin (BE), an endogenous opioid analgesic, are often reported as they relate to acute and chronic pain outcomes. However, little is known about what resting plasma BE levels might reveal about functioning of the endogenous opioid antinociceptive system. This study directly examined associations between resting plasma BE and subsequent endogenous opioid analgesic responses to acute pain in 39 healthy controls and 37 individuals with chronic low back pain (LBP). Resting baseline levels of plasma BE were assessed. Next, participants received opioid blockade (8 mg naloxone i.v.) or placebo in a double-blind, randomized, crossover design. Participants then underwent two acute pain stimuli: finger pressure (FP) pain and ischaemic (ISC) forearm pain. Blockade effects (naloxone minus placebo pain ratings) were derived to index endogenous opioid analgesic function. In placebo condition analyses for both pain stimuli, higher resting BE levels were associated with subsequently greater reported pain intensity (p's < 0.05), with this effect occurring primarily in healthy controls (BE × Participant Type interactions, p's < 0.05). In blockade effect analyses across both pain tasks, higher resting plasma BE predicted less subsequent endogenous opioid analgesia (smaller blockade effects; p's < 0.05). For the ISC task, these links were significantly more prominent in LBP participants (BE × Participant Type Interactions, p's < 0.05). Results suggest that elevated resting plasma BE may be a potential biomarker for reduced endogenous opioid analgesic capacity, particularly among individuals with chronic pain. Potential clinical implications are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.