ArticleMolecular and cellular biology1990
Functional analysis of c-Myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myc promoter.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.Nature communications · 2020Article
- miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis.Oncotarget · 2017Article
- c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells.Leukemia · 2012Article
- An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Genes & development · 2011Article
- Regulation of cyst wall protein promoters by Myb2 in Giardia lamblia.The Journal of biological chemistry · 2008Article
- Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity.Nucleic acids research · 2007Article
- Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.The EMBO journal · 2006Article
- The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells.Oncogene · 2006Article
- Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein.Oncogene · 2003Article
- Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro.Journal of virology · 2003Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
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- Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc.The EMBO journal · 2002Article
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- Review
- Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis.Molecular and cellular biology · 2000Article
- Review
- A-myb is expressed in bovine vascular smooth muscle cells during the late G1-to-S phase transition and cooperates with c-myc to mediate progression to S phase.Molecular and cellular biology · 1997Article
- Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M.Molecular and cellular biology · 1995Article
- Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.The Journal of clinical investigation · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The function of c-Myb protein was revealed by transfecting an expression vector containing the entire c-Myb protein-coding sequence into the murine CTLL-2 T-cell line. Expressions of high levels of c-Myb protein did not alter the expression of several T-cell markers, c-fos mRNA expression, responses to interleukin-2, and growth characteristics of these cells. Interestingly, expression of the c-myc gene was drastically increased in this clone. Further, the c-myb expression plasmid, but not a frameshift mutant of c-myb, enhanced the expression of a hybrid construct of c-myc promoter linked to a reporter gene by 8- to 14-fold. These results demonstrate a role of c-Myb protein in c-myc gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.