Evidence map›Paper›PMID 22336956›Full record

ArticlePharmacogenetics and genomics2012

Celecoxib pathways: pharmacokinetics and pharmacodynamics.

Li Gong, Caroline F Thorn, Monica M Bertagnolli, Tilo Grosser, Russ B Altman, Teri E Klein

3 registry-linked trialsAbstract read
In one paragraph

Article in Pharmacogenetics and genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 91 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331315 phase2completednot on this mapstarted 2013, after this paper: background citation

A Randomized Control Trial Study of the Efficacy of Celecoxib Versus Ketorolac for Perioperative Pain Control

TypeinterventionalSponsorMichael Ulm, MDRan2013 to 2017Enrolled170ConditionsPain, PostoperativeArmsCelecoxib, Ketorolac
NCT04790812 phase4completednot on this mapstarted 2021, after this paper: background citation

Single Dose Oral Celecoxib (With or Without Acetaminophen) for Acute Post-operative Pain Following Impacted Third Molar Surgery.

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2021 to 2023Enrolled65ConditionsPain, PostoperativeArmsCelecoxib, Acetaminophen, Placebo
NCT06516094 phase3completednot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety Study of Celecoxib / Pregabalin / Vitamin B Fixed Dose Combination Versus Celecoxib + Vitamin B Versus Pregabalin + Vitamin B in the Management of Chronic Low Back Pain Mixed Component

TypeinterventionalSponsorLaboratorios Silanes S.A. de C.V.Ran2024 to 2025Enrolled192ConditionsChronic Low-back PainArmsCelecoxib+Pregabalin+Vitamin B fixed dose, Celecoxib + Vitamin B fixed dose, Pregabalin + Vitamin B fixed dose
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026
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  12. Review
  13. Synthesis of novel pyrazole derivatives and neuroprotective effect investigation.Journal of enzyme inhibition and medicinal chemistry · 2025
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li GongDepartment of Genetics, Stanford University, Stanford, California, USA.
Caroline F Thorn
Monica M Bertagnolli
Tilo Grosser
Russ B Altman
Teri E Klein

Funding

PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
THE STANFORD PHARMACOGENETICS KNOWLEDGE BASEU01GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2000 to 2009
$24.0M
NIGMS NIH HHS R24 GM061374NIGMS NIH HHS U01 GM061374NIGMS NIH HHS U01GM61374
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, PharmacologicalAnti-Inflammatory Agents, Non-SteroidalAryl Hydrocarbon HydroxylasesCardiovascular AbnormalitiesCelecoxibCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCytochrome P-450 CYP2C9Genetic Association StudiesHumansInflammationMetabolic Networks and PathwaysPyrazolesSulfonamidesTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalAryl Hydrocarbon HydroxylasesBiomarkers, PharmacologicalCelecoxibCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCYP2C9 protein, humanCytochrome P-450 CYP2C9PTGS1 protein, humanPTGS2 protein, humanPyrazolesSulfonamides

Identifiers

PMID22336956
PMCPMC3303994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.