SynthesisThe Cochrane database of systematic reviews2012
Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour.The Cochrane database of systematic reviews · 2020Pooled it
- Prophylactic management of postpartum haemorrhage in the third stage of labour: an overview of systematic reviews.Systematic reviews · 2018Pooled it
- Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour.The Cochrane database of systematic reviews · 2018Pooled it
- Oxytocin for preventing postpartum haemorrhage (PPH) in non-facility birth settings.The Cochrane database of systematic reviews · 2016Pooled it
- Treatment for primary postpartum haemorrhage.The Cochrane database of systematic reviews · 2014Pooled it
- Prophylactic interventions after delivery of placenta for reducing bleeding during the postnatal period.The Cochrane database of systematic reviews · 2013Pooled it
- Intramuscular versus intravenous oxytocin to prevent postpartum haemorrhage at vaginal delivery: randomised controlled trial.BMJ (Clinical research ed.) · 2018Trial
- Trial
- Intravenous versus intramuscular oxytocin injection for preventing uterine atonic primary postpartum haemorrhage in third stage of labour: A double-blind randomised controlled trial.SAGE open medicine · 2024Article
- Improving the perioperative compliance and quality care in obstetric and paediatric anaesthesia: Challenges and anodynes.Indian journal of anaesthesia · 2020Article
- Lack of controlled studies investigating the risk of postpartum haemorrhage in cesarean delivery after prior use of oxytocin: a scoping review.BMC pregnancy and childbirth · 2017Article
- How effective are the components of active management of the third stage of labor?BMC pregnancy and childbirth · 2013Article
Corrections and comments
- Updated by
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a general agreement that oxytocin given either through the intramuscular or intravenous route is effective in reducing postpartum blood loss. However, it is unclear whether the subtle differences between the mode of action of these routes have any effect on maternal and infant outcomes.
objectivesTo determine the comparative effectiveness and safety of oxytocin administered intramuscularly or intravenously for prophylactic management of the third stage of labour after vaginal birth. SEARCH
methodsWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2011). SELECTION CRITERIA: Randomised trials comparing intramuscular with intravenous oxytocin for prophylactic management of the third stage of labour after vaginal birth. We excluded quasi-randomised trials. DATA COLLECTION AND ANALYSIS: Two review authors planned to independently assess trials for inclusion, assess risk of bias and extract data. MAIN
resultsThe search strategies identified no trials for consideration but we identified one ongoing study. AUTHORS'
conclusionsThere is no evidence from randomised trials to evaluate the comparative benefits and risks of intramuscular and intravenous oxytocin when given to prevent excessive blood loss after vaginal birth. Randomised trials with adequate design and sample sizes are needed to assess whether the route of prophylactic oxytocin after vaginal birth affects maternal or infant outcomes. Such trials should be large enough to detect clinically important differences in major side effects reported in observational studies and also to consider the acceptability of the intervention to mothers and providers as important outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.