SynthesisThe Cochrane database of systematic reviews2012
Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018Pooled it
- Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis.Nutrients · 2017Pooled it
- Different treatment regimens of magnesium sulphate for tocolysis in women in preterm labour.The Cochrane database of systematic reviews · 2015Pooled it
- Premature Rupture of Fetal Membranes: A Narrative Review Integrating Current Evidence and International Guidelines for Optimal Care.Journal of obstetrics gynecology and reproductive sciences · 2026Article
- Effect of maternal serum magnesium and calcium levels on umbilical glial fibrillary acidic protein levels in preterm labor.Scientific reports · 2023Article
- Antenatal magnesium sulfate treatment and risk of necrotizing enterocolitis in preterm infants born at less than 32 weeks of gestation.Scientific reports · 2020Article
- Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.Neural regeneration research · 2018Review
- Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Perinatal neuroprotection update.F1000Research · 2016Review
- Thalamocortical Connectivity Predicts Cognition in Children Born Preterm.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Use and attitudes of obstetricians toward 3 high-risk interventions in MFMU Network hospitals.American journal of obstetrics and gynecology · 2015Article
- What are the Best Animal Models for Testing Early Intervention in Cerebral Palsy?Frontiers in neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effectiveness of antenatal magnesium sulphate for neuroprotection of the fetus, infant, and child prior to very preterm birth, when given to women considered at risk of preterm birth, has been established. There is currently no consensus as to the regimen to use in terms of the dose, duration, the use of repeat dosing and timing.
objectivesTo assess the comparative effectiveness and adverse effects of different magnesium sulphate regimens for neuroprotection of the fetus in women considered at risk of preterm birth. SEARCH
methodsWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2011). SELECTION CRITERIA: Randomised trials comparing different magnesium sulphate regimens when used for neuroprotection of the fetus in women considered at risk of preterm birth. We planned to include cluster trials. We planned to exclude quasi-randomised trials and those with a crossover design. We planned to include trials published as full-text papers, along with those published in abstract form only. DATA COLLECTION AND ANALYSIS: We planned that at least two review authors would assess trial eligibility. MAIN
resultsNo eligible completed trials were identified. AUTHORS'
conclusionsAlthough strong evidence supports the use of antenatal magnesium sulphate for neuroprotection of the fetus prior to very preterm birth, no trials comparing different treatment regimens have been completed. Research should be directed towards comparisons of different dosages and other variations in regimens, evaluating both maternal and infant outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.