Trial reportThe Journal of pediatrics2012
Feasibility study of early blood pressure management in extremely preterm infants.
Trial report in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00874393 (Early Blood Pressure Management in Extremely Preterm Infants Feasibility Pilot Study), which is not on this map. Cited by 27 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Blood Pressure Management in Extremely Preterm Infants Feasibility Pilot Study
Who cites it
27 citing papers in PubMed, 9 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline.Frontiers in pediatrics · 2025Pooled it
- Pooled it
- Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2019Pooled it
- Late (> 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Hypotension in Preterm Infants (HIP) randomised trial.Archives of disease in childhood. Fetal and neonatal edition · 2021Trial
- Use of antihypotensive therapies in extremely preterm infants.Pediatrics · 2013Trial
- Pediatric clinical trials in emergency or intensive care settings using exception from informed consent and waiver of informed consent regulations.World journal of emergency medicine · 2026Article
- Neonatal Shock: Current Dilemmas and Future Research Avenues.Children (Basel, Switzerland) · 2025Review
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews.The Cochrane database of systematic reviews · 2024Review
- Strong Association between Inotrope Administration and Intraventricular Hemorrhage, Gestational Age, and the Use of Fentanyl in Very Low Gestational Age Infants: A Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Overview of the neonatal research network: History, contributions, challenges, and future.Seminars in perinatology · 2022Review
- Vasoactive medications in extremely low gestational age neonates during the first postnatal week.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- How to safeguard the brain of extremely preterm infants?Pediatric research · 2021Article
- Cardiovascular Pharmacological Support Among Preterm Infants in Chinese Referral Center Neonatal Intensive Care Units.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveTo assess the feasibility of a randomized placebo controlled trial (RCT) of blood pressure (BP) management for extremely preterm infants. STUDY
designThis was a prospective pilot RCT of infants 23-0/7 to 26-6/7 weeks gestation who had protocol-defined low BP in the first 24 postnatal hours. Enrolled infants were administered a study infusion (dopamine or placebo) and a study syringe medication (hydrocortisone or placebo).
resultsOf the 366 infants screened, 119 (33%) had low BP, 58 (16%) met all entry criteria, and 10 (3%) were enrolled. A total of 161 infants (44%) were ineligible because they received early indomethacin. Only 17% of eligible infants were enrolled. Problems with consent included insufficient time, parent unavailability, and physician unwillingness to enroll critically ill infants. Two infants were withdrawn from the study because of the potential risk of intestinal perforation with simultaneous administration of hydrocortisone and indomethacin.
conclusionsThis pilot RCT was not feasible because of low eligibility and consent rates. An RCT of BP management for extremely preterm infants may require a waiver of consent for research in emergency care. The frequent use of early indomethacin and the associated risk of intestinal perforation when used with hydrocortisone may limit future investigations to only inotropic medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.