ArticleBioorganic & medicinal chemistry2012
Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.
Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, andJournal of enzyme inhibition and medicinal chemistry · 2023Article
- In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Benzothiazoles from Condensation ofMolecules (Basel, Switzerland) · 2021Review
- New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.European journal of medicinal chemistry · 2021Article
- A study of the structure-affinity relationship in SYA16263; is a DBioorganic & medicinal chemistry · 2021Article
- SYA 013 analogs as moderately selective sigma-2 (σBioorganic & medicinal chemistry · 2019Article
- New analogs of SYA013 as sigma-2 ligands with anticancer activity.Bioorganic & medicinal chemistry · 2019Article
- Copper-Catalyzed, Ceric Ammonium Nitrate MediatedNew journal of chemistry = Nouveau journal de chimie · 2019Article
- Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives.Molecules (Basel, Switzerland) · 2018Article
- Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.Bioorganic & medicinal chemistry · 2016Article
- Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.Bioorganic & medicinal chemistry · 2016Article
- Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.Bioorganic & medicinal chemistry · 2016Article
- Further evaluation of the tropane analogs of haloperidol.Bioorganic & medicinal chemistry letters · 2014Article
- Identification of a new selective dopamine D4 receptor ligand.Bioorganic & medicinal chemistry · 2014Article
- Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.European journal of medicinal chemistry · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Structure-activity relationship studies on 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one (SYA 013), a homopiperazine analog of haloperidol has resulted in an understanding of the effect of structural modifications on binding affinity at dopamine and serotonin receptor subtypes. Further exploration, using bioisosteric replacement strategies has led to the identification of several new agents including compounds 7, 8, 11 and 12 which satisfy the initial criteria for further exploration as new antipsychotic agents. In addition, compound 18, a D(3) selective tropanol, has been identified as having the potential for further optimization into a useful drug which may combat neuropsychiatric diseases.
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Registered trials
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