ArticleThe Journal of allergy and clinical immunology2012
Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.The Journal of allergy and clinical immunology · 2015Trial
- Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Impact of RSV Preventive Strategies on Hospitalizations for Bronchiolitis in Infants.Pediatric pulmonology · 2026Article
- Early-life lung function deficits partially explain the link between maternal asthma and bronchiolitis or asthma in offspring.BMJ open respiratory research · 2026Article
- Prenatal Exposure to Proton Pump Inhibitors and Risk of Serious Infections in Offspring During the First Year of Life: A Nationwide Cohort Study.Drug safety · 2025Article
- In Utero Exposure to Antibiotics and Risk of Serious Infections in the First Year of Life.Drug safety · 2024Article
- Pollen exposure is associated with risk of respiratory symptoms during the first year of life.Allergy · 2022Article
- Breast milk-derived extracellular vesicle miRNAs are associated with maternal asthma and atopy.Epigenomics · 2022Article
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- Urine Levels of γ-Aminobutyric Acid Are Associated with the Severity of Respiratory Syncytial Virus Infection in Infancy.Annals of the American Thoracic Society · 2020Article
- Use of biologics during pregnancy and risk of serious infections in the mother and baby: a Canadian population-based cohort study.BMJ open · 2019Article
- Clinical and Virus Surveillance After the First Wheezing Episode: Special Reference to Rhinovirus A and C Species.The Pediatric infectious disease journal · 2017Article
- [The interactions between microorganisms and the small airways. A paediatric focus].Revue des maladies respiratoires · 2017Review
- Rhinovirus species and clinical characteristics in the first wheezing episode in children.Journal of medical virology · 2016Article
- Article
- Pediatric Asthma and Viral Infection.Archivos de bronconeumologia · 2016Review
- Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention.Current opinion in allergy and clinical immunology · 2016Review
- β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study.BMC medical genetics · 2015Article
- Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy.Pediatric allergy, immunology, and pulmonology · 2015Article
- Recurrent rhinovirus detections in children following a rhinovirus-induced wheezing exacerbation: A retrospective study.International journal of pediatrics and child health · 2015Article
Corrections and comments
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- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRespiratory syncytial virus (RSV) and rhinovirus infections are the most common significant infant respiratory tract illnesses and are associated with increased but differential risks of childhood asthma.
objectiveWe sought to determine whether maternal asthma is associated with higher odds of infant respiratory tract infection with rhinovirus versus RSV and increased infection severity.
methodsMother-infant dyads were enrolled from 2004-2008 during an infant respiratory tract infection (104 with rhinovirus and 279 with RSV). Mothers were classified into mutually exclusive groups (atopic asthma, nonatopic asthma, and no asthma). We determined viral cause using PCR and the severity of the infant's respiratory tract infection using the bronchiolitis severity score. Adjusted relative odds of maternal asthma with viral cause were calculated by using logistic regression. Proportional odds models assessed the association of maternal asthma and infant infection severity.
resultsInfants with a mother with atopic asthma compared with infants whose mothers did not have asthma were more likely to have rhinovirus versus RSV infection (adjusted odds ratio, 2.42; 95% CI, 1.19-4.90). Similarly, among infants with rhinovirus, having a mother with atopic asthma was associated with increased infection severity (adjusted odds ratio, 3.10; 95% CI, 1.21-7.98). This relationship was not seen among infants with RSV.
conclusionsClinically significant rhinovirus infection during infancy was more strongly associated with having a mother with atopic asthma than clinically significant RSV infection. Having a mother with atopic asthma was associated with increased severity of infant rhinovirus but not RSV infections. Infants with rhinovirus were more likely to have a familial atopic predisposition, which might partly explain the subsequent increased asthma risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.