ArticleAllergy2012
Basophils are not the key antigen-presenting cells in allergic patients.
Article in Allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis.The Journal of allergy and clinical immunology · 2017Trial
- Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Review
- Article
- Cellular activation pathways and interaction networks in vascularized composite allotransplantation.Frontiers in immunology · 2023Review
- Basophils control T cell priming through soluble mediators rather than antigen presentation.Frontiers in immunology · 2022Review
- SARS-CoV-2 Induces Cytokine Responses in Human Basophils.Frontiers in immunology · 2022Article
- The α-Gal Syndrome and Potential Mechanisms.Frontiers in allergy · 2021Review
- Tracing Human IgE B Cell Antigen Receptor-Bearing Cells With a Monoclonal Anti-Human IgE Antibody That Specifically Recognizes Non-Receptor-Bound IgE.Frontiers in immunology · 2021Article
- Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.Scientific reports · 2020Article
- Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease.Frontiers in immunology · 2020Review
- Is there a Role of Intravenous Immunoglobulin in Immunologic Recurrent Pregnancy Loss?Journal of immunology research · 2020Review
- Important and specific role for basophils in acute allergic reactions.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Review
- TNature reviews. Immunology · 2018Review
- Transcription factor RBP-J-mediated signalling regulates basophil immunoregulatory function in mouse asthma model.Immunology · 2017Article
- The role of rare innate immune cells in Type 2 immune activation against parasitic helminths.Parasitology · 2017Review
- Demystification of enigma on antigen-presenting cell features of human basophils: data from secondary lymphoid organs.Haematologica · 2017Article
- Granulocytes: New Members of the Antigen-Presenting Cell Family.Frontiers in immunology · 2017Review
- Roles of basophils and mast cells in cutaneous inflammation.Seminars in immunopathology · 2016Review
- The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test.Clinical and translational allergy · 2016Article
- The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune Functions.BioMed research international · 2016Review
Corrections and comments
- Commented on by
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent data obtained in mouse models have initiated a controversy whether basophils are the key antigen-presenting cells (APCs) in allergy. Here, we investigate whether basophils are of importance for the presentation of allergen and the induction of T cell proliferation in allergic patients.
methodsT cells, basophils, and APCs depleted of basophils were purified from allergic patients. Co-culture systems based on purified major allergens were established to study allergen-specific T cell responses using proliferation assays.
resultsOnly co-cultures of T cells with APCs depleted of basophils but not with basophils proliferated in response to allergen. Even addition of IL-3 to T cell-basophil co-cultures failed to induce allergen-specific T cell proliferation.
conclusionsOur data demonstrate by classical in vitro proliferation assays that basophils are not key antigen-presenting cells that promote T cell proliferation in secondary immune responses to allergen in allergic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.