ReviewUpsala journal of medical sciences2012
Localized AL amyloidosis: a suicidal neoplasm?
Review in Upsala journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ¹⁸F-FDG PET/CT: a review of diagnostic and prognostic features in multiple myeloma and related disorders.Clinical and experimental medicine · 2015Pooled it
- Pancreaticoduodenectomy for Mass-Forming Localized Duodenal Amyloidosis: A Case Report.Surgical case reports · 2026Article
- Article
- Exploring the Histopathological Features of Thrombus-Associated Localized Amyloid Deposition: Comprehensive Analysis Employing Immunohistochemistry and Proteomics.International journal of molecular sciences · 2025Article
- Presentation and Outcomes of Localized Immunoglobulin Light Chain Amyloidosis: 14-Year Experience of an Academic Center.Hematological oncology · 2025Article
- Localized light chain amyloidosis of the stomach that regressed after eradication of Helicobacter pylori over 15 years of follow-up: a case report and new hypothesis.Clinical journal of gastroenterology · 2025Article
- Nodular pulmonary amyloidosis diagnosed by ultrasound-guided percutaneous needle biopsy.Respiratory medicine case reports · 2024Article
- A Rare Case of Subcutaneous Amyloidoma Associated with Localized Lymphoplasmacytic Lymphoma: Diagnostic Challenges and Treatment Considerations.The American journal of case reports · 2023Review
- Amyloidogenesis: What Do We Know So Far?International journal of molecular sciences · 2022Review
- Localized light chain amyloidosis: A self-limited plasmacytic B-cell lymphoproliferative disorder.Frontiers in oncology · 2022Review
- Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital.Upsala journal of medical sciences · 2022Article
- Localized gastric amyloidosis diagnosed by endoscopic ultrasound-guided fine-needle aspiration.Clinical journal of gastroenterology · 2021Article
- Series of myocardial FDG uptake requiring considerations of myocardial abnormalities in FDG-PET/CT.Japanese journal of radiology · 2021Review
- A Rare Case of Localized Esophageal Amyloidosis.Internal medicine (Tokyo, Japan) · 2021Article
- Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation.Internal medicine (Tokyo, Japan) · 2021Article
- Localised laryngotracheal amyloidosis: a differential diagnosis not to forget.BMJ case reports · 2021Article
- Extremely Rare Intraoral Presentation of Localized Amyloidosis.Case reports in dentistry · 2021Article
- Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature.Frontiers in surgery · 2021Article
- Case Report: Management of Primary Tracheobronchial Light Chain Amyloidosis in a Patient With Biclonal Gammopathy Using a Systemic Bortezomib-Based Regimen.Frontiers in medicine · 2021Article
- Trigeminal Amyloidoma: A Report of Two Cases and Review of the Literature.Journal of neurological surgery. Part B, Skull base · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although AL amyloidosis usually is a systemic disease, strictly localized AL deposits are not exceptionally rare. Such case reports form a considerable body of published articles. Although both AL amyloidosis types are formed from an N-terminal segment of a monoclonal immunoglobulin light chain, a typical localized AL amyloid differs from the systemic counterpart by the morphological appearance of the amyloid, and presence of clonal plasma cells and of giant cells. In this article it is pointed out that localized AL amyloidosis ('amyloidoma') represents a true plasma cell neoplasm and not a pseudotumor. The pathogenesis of localized AL amyloidosis may differ from that of the systemic type, a suggestion underlined by the fact that localized AL amyloidosis of kappa type is as common as that of lambda origin, in contrast to the systemic form where lambda chains constitute the overwhelming majority of cases. It is suggested that oligomeric assemblies of the produced immunoglobulin light chain are toxic to plasma cells, which in this way commit suicide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.