Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2012
A pilot study assessing adherence to auto-bilevel following a poor initial encounter with CPAP.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of a Novel Positive Pressure Therapy to Rescue Patients Failing to Tolerate CPAP During an Initial Encounter
Phase IV Study of Bi-Level Positive Positive Airway Pressure (BiPAP)Compared to Nasal Continuous Positive Airway Pressure (CPAP) Therapy
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pressure modification or humidification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea.The Cochrane database of systematic reviews · 2019Pooled it
- Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Pooled it
- A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea.Sleep medicine · 2013Trial
- The effect of bilevel ventilation or modified continuous positive airway pressure on treatment adherence in adults with obstructive sleep apnea: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Surgical treatment for obstructive sleep apnea: effect on sleep architecture.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Observational
- Switch of Nocturnal Non-Invasive Positive Pressure Ventilation (NPPV) in Obstructive Sleep Apnea (OSA).Journal of clinical medicine · 2022Article
- A CPAP data-based algorithm for automatic early prediction of therapy adherence.Sleep & breathing = Schlaf & Atmung · 2021Article
- Determinants of bilevel therapy in the management of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2021Observational
- Compliance after switching from CPAP to bilevel for patients with non-compliant OSA: big data analysis.BMJ open respiratory research · 2019Article
- Effect of adherence on daytime sleepiness, fatigue, depression and sleep quality in the obstructive sleep apnea/hypopnea syndrome patients undertaking nasal continuous positive airway pressure therapy.Patient preference and adherence · 2017Article
- Pressure-Relief Features of Fixed and Autotitrating Continuous Positive Airway Pressure May Impair Their Efficacy: Evaluation with a Respiratory Bench Model.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Efficacy of Bilevel-auto Treatment in Patients with Obstructive Sleep Apnea Not Responsive to or Intolerant of Continuous Positive Airway Pressure Ventilation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Article
- New developments in the use of positive airway pressure for obstructive sleep apnea.Journal of thoracic disease · 2015Review
- On the cutting edge of obstructive sleep apnoea: where next?The Lancet. Respiratory medicine · 2015Review
- Article
- Adult obstructive sleep apnoea.Lancet (London, England) · 2014Review
- The Quest to Improve CPAP Adherence--PAP Potpourri is Still Not the Answer, but more research is needed.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012Article
- Driving on "auto": hands-on is more effective than hands-free.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012Article
- The quest to improve CPAP adherence--PAP potpourri is not the answer.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012Article
- Artificial intelligence for predicting adherence to CPAP therapy in obstructive sleep apnoea: A systematic review.Digital healthArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
STUDY
objectivesWe hypothesized that early intervention with an auto bilevel device would improve treatment adherence compared to CPAP among OSA patients with a poor initial experience with lab-based CPAP titration.
methodsPatients with a poor initial CPAP experience were recruited for this parallel group, randomized, double-blind, controlled pilot study. After an in-lab titration, patients were randomized with either an auto-bilevel device or CPAP. Treatment adherence and functioning were assessed at 90 days.
resultsWe enrolled 51 subjects, with 47 completing the protocol. Groups were equally matched for gender, age, education, and OSA severity. There was no significant difference in the proportion of compliant subjects (≥ 4 h/night) between the auto bilevel and CPAP groups (62% vs. 54%; p = 0.624) after 90 days of use. Functional outcomes significantly improved in both groups during treatment use (p < 0.001) but did not differ between groups.
conclusionsThere was no statistically significant difference in adherence between the auto bilevel and CPAP groups in this study. Patients with a poor initial CPAP exposure may still achieve an acceptable long-term clinical outcome. Both groups demonstrated comparably significant improvements in functional outcomes, sleepiness, and fatigue complaints over the treatment period. CLINICAL TRIALS INFORMATION: NCT00635206 ClinicalTrials.gov
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.