ArticleInternational journal of nanomedicine2012
Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 102 citations in OpenAlex.
- Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets.Journal of functional biomaterials · 2024Review
- A double-edged sword: The complex interplay between engineered nanoparticles and platelets.Bioengineering & translational medicine · 2024Review
- Human and environmental impacts of nanoparticles: a scoping review of the current literature.BMC public health · 2023Article
- Comparative Evaluation of the Effects of Amorphous Silica Nanoparticles on the Erythrocytes of Wistar Normotensive and Spontaneously Hypertensive Rats.International journal of molecular sciences · 2023Article
- Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications.International journal of pharmaceutics: X · 2022Review
- Ethyl Hydroxyethyl Cellulose-A Biocompatible Polymer Carrier in Blood.International journal of molecular sciences · 2022Article
- CuPharmaceutics · 2022Article
- Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells.Pharmaceutics · 2022Article
- Silicon Carbide Technology for Advanced Human Healthcare Applications.Micromachines · 2022Review
- Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect.Pharmaceutics · 2021Article
- Immunocompatibility of a new dual modality contrast agent based on radiolabeled iron-oxide nanoparticles.Scientific reports · 2021Article
- PLGA-PEG Nanoparticles Show Minimal Risks of Interference with Platelet Function of Human Platelet-Rich Plasma.International journal of molecular sciences · 2020Article
- Toxicity Evaluation of Nanostructured Silica Orally Administered to Rats: Influence on Immune System Function.Nanomaterials (Basel, Switzerland) · 2020Article
- Identification of physicochemical properties that modulate nanoparticle aggregation in blood.Beilstein journal of nanotechnology · 2020Article
- Methodological variations affect the release of VEGF in vitro and fibrinolysis' time from platelet concentrates.PloS one · 2020Article
- Indocyanine green modified silica shells for colon tumor marking.Applied surface science · 2020Article
- The Hemocompatibility of Nanoparticles: A Review of Cell-Nanoparticle Interactions and Hemostasis.Cells · 2019Review
- Effect of Size and Concentration of PLGA-PEG Nanoparticles on Activation and Aggregation of Washed Human Platelets.Pharmaceutics · 2019Article
- Pulmonary deregulation of expression ofInternational journal of nanomedicine · 2019Article
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmorphous silica nanoparticles (SiNP) can be used in medical technologies and other industries leading to human exposure. However, an increased number of studies indicate that this exposure may result in cardiovascular inflammation and damage. A high ratio of nitric oxide to peroxynitrite concentrations ([NO]/[ONOO(-)]) is crucial for cardiovascular homeostasis and platelet hemostasis. Therefore, we studied the influence of SiNP on the platelet [NO]/[ONOO(-)] balance and platelet aggregation.
methodsNanoparticle-platelet interaction was examined using transmission electron microscopy. Electrochemical nanosensors were used to measure the levels of NO and ONOO(-) released by platelets upon nanoparticle stimulation. Platelet aggregation was studied using light aggregometry, flow cytometry, and phase contrast microscopy.
resultsAmorphous SiNP induced NO release from platelets followed by a massive stimulation of ONOO(-) leading to an unfavorably low [NO]/[ONOO(-)] ratio. In addition, SiNP induced an upregulation of selectin P expression and glycoprotein IIb/IIIa activation on the platelet surface membrane, and led to platelet aggregation via adenosine diphosphate and matrix metalloproteinase 2-dependent mechanisms. Importantly, all the effects on platelet aggregation were inversely proportional to nanoparticle size.
conclusionsThe exposure of platelets to amorphous SiNP induces a critically low [NO]/[ONOO(-)] ratio leading to platelet aggregation. These findings provide new insights into the pharmacological profile of SiNP in platelets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.