ArticleInternational journal of nanomedicine2012
Fructose-enhanced reduction of bacterial growth on nanorough surfaces.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Antimicrobial-coated endotracheal tubes: A narrative review.Journal of critical care · 2026Review
- An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention.Pharmaceutics · 2024Review
- Antimicrobial Solutions for Endotracheal Tubes in Prevention of Ventilator-Associated Pneumonia.Materials (Basel, Switzerland) · 2023Review
- Fructose potentiates the protective efficiency of liveFrontiers in immunology · 2023Article
- Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems.Foods (Basel, Switzerland) · 2022Article
- Antibiotic resistant bacteria: A bibliometric review of literature.Frontiers in public health · 2022Review
- Antimicrobial Coating: Tracheal Tube Application.International journal of nanomedicine · 2022Review
- Short Communication: Fructose-Enhanced Antibacterial Activity of Self-Assembled Nano-Peptide Amphiphiles for Treating Antibiotic-Resistant Bacteria.International journal of nanomedicine · 2020Article
- The antimicrobial activity of nanoparticles: present situation and prospects for the future.International journal of nanomedicine · 2017Review
- Portable microfluidic integrated plasmonic platform for pathogen detection.Scientific reports · 2015Article
- Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets.Scientific reports · 2015Article
- Nanomechanical motion ofApplied physics letters · 2014Article
- Advances in plasmonic technologies for point of care applications.Chemical reviews · 2014Review
- Gold-functionalized magnetic nanoparticles restrict growth of Pseudomonas aeruginosa.International journal of nanomedicine · 2014Article
- Nanostructured substrates for isolation of circulating tumor cells.Nano today · 2013Article
- Short communication: Carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation.International journal of nanomedicine · 2013Article
- Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.International journal of nanomedicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients on mechanical ventilators for extended periods of time often face the risk of developing ventilator-associated pneumonia. During the ventilation process, patients incapable of breathing are intubated with polyvinyl chloride (PVC) endotracheal tubes (ETTs). PVC ETTs provide surfaces where bacteria can attach and proliferate from the contaminated oropharyngeal space to the sterile bronchoalveolar area. To overcome this problem, ETTs can be coated with antimicrobial agents. However, such coatings may easily delaminate during use. Recently, it has been shown that changes in material topography at the nanometer level can provide antibacterial properties. In addition, some metabolites, such as fructose, have been found to increase the efficiency of antibiotics used to treat Staphylococcus aureus (S. aureus) infections. In this study, we combined the antibacterial effect of nanorough ETT topographies with sugar metabolites to decrease bacterial growth and biofilm formation on ETTs. We present for the first time that the presence of fructose on the nanorough surfaces decreases the number of planktonic S. aureus bacteria in the solution and biofilm formation on the surface after 24 hours. We thus envision that this method has the potential to impact the future of surface engineering of biomaterials leading to more successful clinical outcomes in terms of longer ETT lifetimes, minimized infections, and decreased antibiotic usage; all of which can decrease the presence of antibiotic resistant bacteria in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.