ArticleClinical interventions in aging2012
Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).
Article in Clinical interventions in aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Apolipoprotein E Genotype Moderation of the Association Between Physical Activity and Brain Health. A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Association of fall rate and functional status byOncotarget · 2022Trial
- Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study.NeuroImage. Clinical · 2022Trial
- The influence of a 16-week exercise program, APOE status, and age on executive function task performance: A randomized trial.Experimental gerontology · 2021Trial
- Trial
- The effect of an interactive cycling training on cognitive functioning in older adults with mild dementia: study protocol for a randomized controlled trial.BMC geriatrics · 2017Trial
- The mediating role of depression on the association between physical activity and cognitive function among older adults.Frontiers in aging neuroscience · 2025Article
- Lower alanine aminotransferase levels are associated with increased all-cause and cardiovascular mortality in nonalcoholic fatty liver patients.World journal of hepatology · 2023Article
- Physical fitness mediates the association between age and cognition in healthy adults.Aging clinical and experimental research · 2021Article
- RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus.Frontiers in molecular neuroscience · 2018Article
- Article
- Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults-The Reasons for Geographic and Racial Differences in Stroke Study.Journal of the American Geriatrics Society · 2015Article
- Cardiorespiratory fitness and accelerated cognitive decline with aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?Molecular psychiatry · 2013Review
- The Impact of Multiple Dimensions of Socioeconomic Status on Physical Functioning Across the Life Course.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.
designCross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988-1994).
settingUS noninstitutionalized population. PARTICIPANTS AND
methodsFrom a sample of 7159, aged ≥60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus.
resultsIn the initial bivariate analysis, non-ɛ4 carriers and ɛ4-heterozygotes performed better than ɛ4-homozygotes in the 60-69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-ɛ4 carriers (P = 0.014), but not in ɛ4 carriers (P = 0.887). At ≥70 years, PA also correlated with higher adjusted SMSE scores in non-ɛ4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12).
conclusionIn a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. Experimental studies are needed to determine whether or not PA can attenuate cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.