ArticleThe Journal of biological chemistry2012
Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line.Iranian journal of basic medical sciences · 2021Article
- Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine.Pharmacogenomics and personalized medicine · 2021Review
- Targeting AKT for cancer therapy.Expert opinion on investigational drugs · 2019Review
- Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3.International journal of molecular sciences · 2018Article
- Adaptations to Endurance and Strength Training.Cold Spring Harbor perspectives in medicine · 2018Review
- Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle.Scientific reports · 2017Article
- Article
- Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.International journal of clinical and experimental pathology · 2015Article
- Article
- Mutant TP53 posttranslational modifications: challenges and opportunities.Human mutation · 2014Review
- AKT mediates actinomycin D-induced p53 expression.Oncotarget · 2014Article
- Emerging roles for chromatin as a signal integration and storage platform.Nature reviews. Molecular cell biology · 2013Review
- Diverse mechanisms of AKT pathway activation in human malignancy.Current cancer drug targets · 2013Review
- Article
- PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.Nature communications · 2013Article
- PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.Nature structural & molecular biology · 2012Article
Corrections and comments
- Retraction · 2016-10-21Duplication of Data · Duplication of/in Image · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Manipulation of Images ·
- Retracted
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Akt regulates a diverse array of cellular functions, including cell survival, proliferation, differentiation, and metabolism. Although a number of molecules have been identified as upstream regulators and downstream targets of Akt, the mechanisms by which Akt regulates these cellular processes remain elusive. Here, we demonstrate that a novel transcription factor, PHF20/TZP (referring to Tudor and zinc finger domain containing protein), binds to Akt and induces p53 expression at the transcription level. Knockdown of PHF20 significantly reduces p53. PHF20 inhibits cell growth, DNA synthesis, and cell survival. Akt phosphorylates PHF20 at Ser(291) in vitro and in vivo, which results in its translocation from the nucleus to the cytoplasm and attenuation of PHF20 function. These data indicate that PHF20 is a substrate of Akt and plays a role in Akt cell survival/growth signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.