ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2012
Unveiling Mycoplasma hyopneumoniae promoters: sequence definition and genomic distribution.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Phenotypic and genetic insights into efflux pump mechanism inFrontiers in microbiology · 2023Article
- The influence of regulatory elements on Mycoplasma hyopneumoniae 7448 transcriptional response during oxidative stress and heat shock.Molecular biology reports · 2022Article
- Integrative characterization of the near-minimal bacterium Mesoplasma florum.Molecular systems biology · 2020Article
- Pharmacokinetic/Pharmacodynamic Integration of Doxycycline AgainstFrontiers in pharmacology · 2019Article
- Global analysis of sRNA target genes in Mycoplasma hyopneumoniae.BMC genomics · 2018Article
- A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants.Nature communications · 2017Article
- Article
- Functional characterization of the principal sigma factor RpoD of phytoplasmas via an in vitro transcription assay.Scientific reports · 2015Article
- A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium.Nucleic acids research · 2015Article
- Intrinsic terminators in Mycoplasma hyopneumoniae transcription.BMC genomics · 2015Article
- Genome organization in Mycoplasma hyopneumoniae: identification of promoter-like sequences.Molecular biology reports · 2014Article
- Article
- Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae.Veterinary research · 2013Article
- Evidence classification of high-throughput protocols and confidence integration in RegulonDB.Database : the journal of biological databases and curation · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several Mycoplasma species have had their genome completely sequenced, including four strains of the swine pathogen Mycoplasma hyopneumoniae. Nevertheless, little is known about the nucleotide sequences that control transcriptional initiation in these microorganisms. Therefore, with the objective of investigating the promoter sequences of M. hyopneumoniae, 23 transcriptional start sites (TSSs) of distinct genes were mapped. A pattern that resembles the σ(70) promoter -10 element was found upstream of the TSSs. However, no -35 element was distinguished. Instead, an AT-rich periodic signal was identified. About half of the experimentally defined promoters contained the motif 5'-TRTGn-3', which was identical to the -16 element usually found in Gram-positive bacteria. The defined promoters were utilized to build position-specific scoring matrices in order to scan putative promoters upstream of all coding sequences (CDSs) in the M. hyopneumoniae genome. Two hundred and one signals were found associated with 169 CDSs. Most of these sequences were located within 100 nucleotides of the start codons. This study has shown that the number of promoter-like sequences in the M. hyopneumoniae genome is more frequent than expected by chance, indicating that most of the sequences detected are probably biologically functional.
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Registered trials
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