ArticlemBio2012
A microbial association with autism.
Article in mBio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Potential of Salivary Biomarkers in Autism Research: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial.Journal of diabetes investigation · 2022 · on this mapTrial
- Mendelian randomization study reveals causal association between skin microbiome and skin cancers.Scientific reports · 2025Article
- Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing.Frontiers in molecular biosciences · 2025Article
- Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD.Neurotoxicity research · 2019Article
- Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice.BioMed research international · 2018Article
- Interactions between multiple helminths and the gut microbiota in wild rodents.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Human Microbiome: When a Friend Becomes an Enemy.Archivum immunologiae et therapiae experimentalis · 2015Review
- Xenobiotics: Interaction with the Intestinal Microflora.ILAR journal · 2015Review
- Gut microbiome in Down syndrome.PloS one · 2014Observational
- Translational toxicology: a developmental focus for integrated research strategies.BMC pharmacology & toxicology · 2013Article
- Learning and memory ... and the immune system.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.Nature genetics · 2013Article
- The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study.PloS one · 2013Article
- Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified.PloS one · 2013Article
- Does the human gut microbiota contribute to the etiology of autism spectrum disorders?Digestive diseases and sciences · 2012Article
- The gut: a triggering place for autism - possibilities and challenges.Microbial ecology in health and disease · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a heterogeneous group of complex developmental disabilities that result from a number of possible etiologies. There are a well-known number of comorbidities associated with autism spectrum disorders (ASD), including, commonly, gastrointestinal (GI) pathology, which can include variable combinations of constipation, diarrhea, abdominal pain, gastroesophageal reflux, and vomiting. An American Academy of Pediatrics consensus panel has recommended that prospective studies be carried out to determine the prevalence of GI disorders in ASD and their pathophysiologic basis. In a recent article, Williams et al. [B. L. Williams, M. Hornig, T. Parekh, and W. I. Lipkin, mBio 3(1):e00261-11, 2012] have provided one such study of autism with GI comorbidities by presenting evidence of Sutterella species in ileal mucosal biopsy specimens from patients diagnosed with ASD but not in control children with GI symptoms, suggesting a specific role for Sutterella in ASD. Sutterella sequences represented ~1 to 7% of the total bacterial sequences, and this is a very large effect size on the ileal mucosal composition of the autism phenotype, rivaling or perhaps exceeding the effect size of the ileal Crohn's disease phenotype. This study opens a new field of investigation to study the etiology or consequences of GI comorbidities in ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.