SynthesisThe oncologist2012
Radiation-induced sarcoma of the breast: a systematic review.
Synthesis in The oncologist, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04749446 (Breast Sarcomas), which is not on this map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breast Sarcomas: A Retrospective Analysis of Clinical Features and Outcomes
Who cites it
54 citing papers in PubMed.
- Hypofractionated radiotherapy with hyperthermia in radiation-associated and in-volume recurrent soft tissue sarcomas of the extremities and trunk wall: results of a proof-of-concept prospective trial.Radiation oncology (London, England) · 2025Trial
- Clinical and prognostic insights into radiation-associated angiosarcoma: a multi-institutional analysis.Radiation oncology (London, England) · 2026Article
- Article
- Metachronous head and neck osteosarcoma in an elderly patient: A rare case report with prior verrucous carcinoma.Medicine · 2025Article
- Histopathological Subtypes of Cutaneous Melanoma: Prognostic and Molecular Implications.Cureus · 2025Review
- TRPS1 expression in breast angiosarcoma.Virchows Archiv : an international journal of pathology · 2025Article
- Angiosarcoma: a 10-year retrospective study from a high-volume UK regional referral centre.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Radiation-Induced Breast Angiosarcoma-A Single-Institution Experience.Diagnostics (Basel, Switzerland) · 2024Article
- Clinicopathological and genetic characterization of radiotherapy-induced undifferentiated pleomorphic sarcoma following breast cancer: a case series of three tumors and comprehensive literature review.Diagnostic pathology · 2024Article
- Radiation-Associated Angiosarcoma of the Breast: The State of the Art of a Rare and Aggressive Disease.Journal of personalized medicine · 2024Review
- Radiation‑induced pleomorphic liposarcoma after hypofractionated radiotherapy following breast‑conserving surgery: A case report and literature review.Oncology letters · 2024Article
- Management of soft tissue sarcomas of the chest wall: a comprehensive overview.Journal of thoracic disease · 2024Review
- Article
- Angiosarcoma of the Breast: Overview of Current Data and Multimodal Imaging Findings.Journal of imaging · 2023Review
- Breast Sarcomas-How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights.Diagnostics (Basel, Switzerland) · 2023Article
- Radiation-Induced Sarcomas of the Breast: A Review of a 20-Year Single-Center Experience.Cureus · 2023Article
- Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study.Therapeutic advances in medical oncology · 2023Article
- Clinical Impact of Systemic Staging Studies in Secondary Breast Angiosarcoma.Surgery in practice and science · 2022Article
- Angiosarcoma of breast and chest wall complicated with tuberculous empyema: A case report.Thoracic cancer · 2022Article
- Clinical and Molecular Insights of Radiation-Induced Breast Sarcomas: Is There Hope on the Horizon for Effective Treatment of This Aggressive Disease?International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRadiation-induced sarcoma (RIS) is a rare, aggressive malignancy. Breast cancer survivors treated with radiotherapy constitute a large fraction of RIS patients. To evaluate evidenced-based practices for RIS treatment, we performed a systematic review of the published English-language literature.
methodsWe performed a systematic keyword search of PubMed for original research articles pertaining to RIS of the breast. We classified and evaluated the articles based on hierarchical levels of scientific evidence.
resultsWe identified 124 original articles available for analysis, which included 1,831 patients. No randomized controlled trials involving RIS patients were found. We present the best available evidence for the etiology, comparative biology to primary sarcoma, prognostic factors, and treatment options for RIS of the breast.
conclusionAlthough the evidence to guide clinical practice is limited to single institutional cohort studies, registry studies, case-control studies, and case reports, we applied the available evidence to address clinically relevant questions related to best practice in patient management. Surgery with widely negative margins remains the primary treatment of RIS. Unfortunately, the role of adjuvant and neoadjuvant chemotherapy remains uncertain. This systematic review highlights the need for additional well-designed studies to inform the management of RIS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.