ArticleMagnetic resonance in medicine2012
Comparing localized and nonlocalized dynamic 31P magnetic resonance spectroscopy in exercising muscle at 7 T.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Pooled it
- Dynamic multivoxel-localizedNMR in biomedicine · 2018Trial
- Exercising calf muscle T₂∗ changes correlate with pH, PCr recovery and maximum oxidative phosphorylation.NMR in biomedicine · 2014Trial
- Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle.NMR in biomedicine · 2026Article
- Effects of an active exoskeleton on the muscle activity of the erector spinae and biceps femoris muscles during lifting with symmetric stoop and squat technique.Frontiers in bioengineering and biotechnology · 2026Article
- Article
- FunctionalNMR in biomedicine · 2025Article
- Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy.Nature communications · 2024Article
- Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleavedScientific reports · 2024Article
- Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential.NMR in biomedicine · 2022Review
- DynamicScientific reports · 2021Article
- Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.Magnetic resonance in medicine · 2021Article
- Article
- Whole brainMagnetic resonance in medicine · 2020Article
- A Review of Non-IEEE open journal of engineering in medicine and biology · 2020Article
- Magnetic Resonance Imaging of the Musculoskeletal System at 7T: Morphological Imaging and Beyond.Topics in magnetic resonance imaging : TMRI · 2019Review
- Review
- Oxidative capacity varies along the length of healthy human tibialis anterior.The Journal of physiology · 2018Article
- Dynamic phosphocreatine imaging with unlocalized pH assessment of the human lower leg muscle following exercise at 3T.Magnetic resonance in medicine · 2018Article
- In-vivoAnalytical biochemistry · 2017Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
By improving spatial and anatomical specificity, localized spectroscopy can enhance the power and accuracy of the quantitative analysis of cellular metabolism and bioenergetics. Localized and nonlocalized dynamic (31)P magnetic resonance spectroscopy using a surface coil was compared during aerobic exercise and recovery of human calf muscle. For localization, a short echo time single-voxel magnetic resonance spectroscopy sequence with adiabatic refocusing (semi-LASER) was applied, enabling the quantification of phosphocreatine, inorganic phosphate, and pH value in a single muscle (medial gastrocnemius) in single shots (T(R) = 6 s). All measurements were performed in a 7 T whole body scanner with a nonmagnetic ergometer. From a series of equal exercise bouts we conclude that: (a) with localization, measured phosphocreatine declines in exercise to a lower value (79 ± 7% cf. 53 ± 10%, P = 0.002), (b) phosphocreatine recovery shows shorter half time (t(1/2) = 34 ± 7 s cf. t(1/2) = 42 ± 7 s, nonsignificant) and initial postexercise phosphocreatine resynthesis rate is significantly higher (32 ± 5 mM/min cf. 17 ± 4 mM/min, P = 0.001) and (c) in contrast to nonlocalized (31)P magnetic resonance spectroscopy, no splitting of the inorganic phosphate peak is observed during exercise or recovery, just an increase in line width during exercise. This confirms the absence of contaminating signals originating from weaker-exercising muscle, while an observed inorganic phosphate line broadening most probably reflects variations across fibers in a single muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.