ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- The effect of SSRIs on fear learning: a systematic review and meta-analysis.Psychopharmacology · 2023Pooled it
- Multiple-context extinction strengthens fear suppression through hippocampal dopamine D2R-dependent memory updating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation.Psychopharmacology · 2024Article
- Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription.Cell genomics · 2023Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- Blueprints for measuring natural behavior.iScience · 2022Review
- Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges.Alcohol (Fayetteville, N.Y.) · 2022Review
- CB2 cannabinoid receptor expression is increased in 129S1/SvImJ mice: behavioral consequences.Frontiers in pharmacology · 2022Article
- Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?International journal of molecular sciences · 2021Review
- Central amygdala micro-circuits mediate fear extinction.Nature communications · 2021Article
- Intranasal oxytocin compensates for estrus cycle-specific reduction of conditioned safety memory in rats: Implications for psychiatric disorders.Neurobiology of stress · 2021Article
- Altered sleep behavior in a genetic mouse model of impaired fear extinction.Scientific reports · 2021Article
- The endocannabinoid system in the amygdala and modulation of fear.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat.eLife · 2020Article
- Turning strains into strengths for understanding psychiatric disorders.Molecular psychiatry · 2020Review
- Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice.Neurobiology of stress · 2020Article
- Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction.Behavioural brain research · 2020Article
- Chronic inhibition of GABA synthesis in the infralimbic cortex facilitates conditioned safety memory and reduces contextual fear.Translational psychiatry · 2020Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
Abstract
Mood and anxiety disorders develop in some but not all individuals following exposure to stress and psychological trauma. However, the factors underlying individual differences in risk and resilience for these disorders, including genetic variation, remain to be determined. Isogenic inbred mouse strains provide a valuable approach to elucidating these factors. Here, we performed a comprehensive examination of the extinction-impaired 129S1/SvImJ (S1) inbred mouse strain for multiple behavioral, autonomic, neuroendocrine, and corticolimbic neuronal morphology phenotypes. We found that S1 exhibited fear overgeneralization to ambiguous contexts and cues, impaired context extinction and impaired safety learning, relative to the (good-extinguishing) C57BL/6J (B6) strain. Fear overgeneralization and impaired extinction was rescued by treatment with the front-line anxiety medication fluoxetine. Telemetric measurement of electrocardiogram signals demonstrated autonomic disturbances in S1 including poor recovery of fear-induced suppression of heart rate variability. S1 with a history of chronic restraint stress displayed an attenuated corticosterone (CORT) response to a novel, swim stressor. Conversely, previously stress-naive S1 showed exaggerated CORT responses to acute restraint stress or extinction training, insensitivity to dexamethasone challenge, and reduced hippocampal CA3 glucocorticoid receptor mRNA, suggesting downregulation of negative feedback control of the hypothalamic-pituitary-adrenal axis. Analysis of neuronal morphology in key neural nodes within the fear and extinction circuit revealed enlarged dendritic arbors in basolateral amygdala neurons in S1, but normal infralimbic cortex and prelimbic cortex dendritic arborization. Collectively, these data provide convergent support for the utility of the S1 strain as a tractable model for elucidating the neural, molecular and genetic basis of persistent, excessive fear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.