ArticleNature communications2012
Dynamics of anterior-posterior axis formation in the developing mouse embryo.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- Mechanical cues regulateMaterials today. Bio · 2026Article
- Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis.Stem cell reports · 2025Article
- Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification.Regenerative therapy · 2025Article
- Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.Nature communications · 2025Article
- Embryoid bodies as a model system for exploring early human embryonic development.Journal of assisted reproduction and genetics · 2025Review
- Basement membrane perforations guide anterior-posterior axis formation.Nature communications · 2025Article
- Maternal intestinal L. vaginalis facilitates embryo implantation and survival through enhancing uterine receptivity in sows.Microbiome · 2025Article
- Early autonomous patterning of the anteroposterior axis in gastruloids.Development (Cambridge, England) · 2024Article
- Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies.Scientific reports · 2024Article
- Review
- Distinct pathways drive anterior hypoblast specification in the implanting human embryo.Nature cell biology · 2024Article
- Topical section: embryonic models (2023) for Current Opinion in Genetics & Development.Current opinion in genetics & development · 2024Review
- A comprehensive review: synergizing stem cell and embryonic development knowledge in mouse and human integrated stem cell-based embryo models.Frontiers in cell and developmental biology · 2024Review
- The evolution of embryo models.Nature methods · 2023Article
- The in vitro culture of mammalian embryos.Nature methods · 2023Article
- Article
- Embryo-uterine interaction coordinates mouse embryogenesis during implantation.The EMBO journal · 2023Article
- Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos.National science review · 2023Article
- Progression of the pluripotent epiblast depends upon the NMD factor UPF2.Development (Cambridge, England) · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The development of an anterior-posterior (AP) polarity is a crucial process that in the mouse has been very difficult to analyse, because it takes place as the embryo implants within the mother. To overcome this obstacle, we have established an in-vitro culture system that allows us to follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP polarity. Here we use this system to show that the AVE originates in the implanting blastocyst, but that additional cells subsequently acquire AVE characteristics. These 'older' and 'younger' AVE domains coalesce as the egg cylinder emerges from the blastocyst structure. Importantly, we show that AVE migration is led by cells expressing the highest levels of AVE marker, highlighting that asymmetry within the AVE domain dictates the direction of its migration. Ablation of such leading cells prevents AVE migration, suggesting that these cells are important for correct establishment of the AP axis.
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