ReviewEuropean journal of human genetics : EJHG2012
Syndactyly: phenotypes, genetics and current classification.
Review in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 174 citations in OpenAlex.
- Long-Term Patient-Centered Outcomes After Congenital Syndactyly Reconstruction: Aesthetic, Functional, and Psychosocial Assessment.Journal of clinical medicine · 2026Article
- Polydactyly and syndactyly in a Chinese family with Floating-Harbor syndrome: an expansion of the clinical phenotype.Frontiers in genetics · 2026Article
- Surgical Approaches and Outcomes for 69 First Web Space Congenital Syndactyly Cases of the Hand.Journal of hand surgery global online · 2025Article
- POGLUT2/3 mediated EGF O-glucosylation promotes separation of digits 2 and 3 by influencing fibrillin network reorganization, signaling, and cell dynamics.Developmental biology · 2025Article
- Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.Nature ecology & evolution · 2025Article
- Delayed Surgical Management of Congenital Syndactyly Improves Range of Motion: A Long-Term Follow-Up.Journal of clinical medicine · 2025Article
- Review
- Polydactyly and syndactyly linked to GLI3 and TBX5 mutations: A pediatric case report.Global medical genetics · 2025Article
- Surgical Management of Foot Syndactyly: The State of the Art and a Treatment Algorithm Based on a Literature Review.Journal of clinical medicine · 2025Review
- Case Report: Congenital absence of the fifth metacarpal with polydactyly and syndactyly.Frontiers in pediatrics · 2025Article
- The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice.Bone research · 2024Article
- Epidemiology of congenital polydactyly and syndactyly in Hunan Province, China.BMC pregnancy and childbirth · 2024Article
- A Complex Case of Clino-Syndactyly with Fourth Metacarpal Aplasia.Life (Basel, Switzerland) · 2023Article
- Sequence Variants inMolecular syndromology · 2023Article
- The changing epidemiology of syndactyly in Chinese newborns: a nationwide surveillance-based study.BMC pregnancy and childbirth · 2023Article
- A newborn male with Myhre syndrome, hearing loss, and complete syndactyly of fingers 3-4.Molecular genetics & genomic medicine · 2023Review
- Review
- Keeping you on your toes: Smith-Lemli-Opitz Syndrome is an easily missed cause of developmental delays.Clinical case reports · 2023Article
- Polydactyly: Clinical and molecular manifestations.World journal of orthopedics · 2023Review
- Burden of congenital and hereditary anomalies in the war-affected territory at Pakistan-Afghanistan border.Asian biomedicine : research, reviews and news · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syndactyly is one of the most common hereditary limb malformations depicting the fusion of certain fingers and/or toes. It may occur as an isolated entity or a component of more than 300 syndromic anomalies. Syndactylies exhibit great inter- and intra-familial clinical variability. Even within a subject, phenotype can be unilateral or bilateral and symmetrical or asymmetrical. At least nine non-syndromic syndactylies with additional sub-types have been characterized. Most of the syndactyly types are inherited as autosomal dominant but two autosomal recessive and an X-linked recessive entity have also been described. Whereas the underlying genes/mutations for types II-1, III, IV, V, and VII have been worked out, the etiology and molecular basis of the other syndactyly types remain unknown. In this communication, based on an overview of well-characterized isolated syndactylies, their cardinal phenotypes, inheritance patterns, and clinical and genetic heterogeneities, a 'current classification scheme' is presented. Despite considerable progress in the understanding of syndactyly at clinical and molecular levels, fundamental questions regarding the disturbed developmental mechanisms leading to fused digits, remain to be answered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.