ArticleThe Pediatric infectious disease journal2012
Epidemiology, risk factors and outcome of Candida parapsilosis bloodstream infection in children.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Activity of Isavuconazole and Comparator Agents Against Pediatric Isolates From Invasive Fungal Infections.Journal of the Pediatric Infectious Diseases Society · 2026Article
- Identification ofMicrobiology spectrum · 2026Article
- Epidemiology of Candidemia in Children and Neonates in Korea, 2009-2018: A Multi-Center Study.Journal of Korean medical science · 2025Article
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- PediatricJournal of fungi (Basel, Switzerland) · 2025Article
- Epidemiological characteristics of pediatric patients with invasive candidiasis in an intensive care unit in southwestern ColombiaBiomedica : revista del Instituto Nacional de Salud · 2025Observational
- Article
- Candida parapsilosis complex in the clinical setting.Nature reviews. Microbiology · 2024Review
- Overview ofCurrent medical mycology · 2024Article
- Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.The Lancet. Microbe · 2023Review
- InvasiveMicroorganisms · 2023Article
- Epidemiology and associated risk factors for candidemia in a Canadian tertiary paediatric hospital: An 11-year review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
- Genotypic Diversity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.Microbiology spectrum · 2021Article
- Risk Factors and Outcomes of Recurrent Candidemia in Children: Relapse or Re-Infection?Journal of clinical medicine · 2019Article
- Candidemia due to uncommon Candida species in children: new threat and impacts on outcomes.Scientific reports · 2018Observational
- Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates.BMC infectious diseases · 2018Article
- The N-Terminus of Human Lactoferrin Displays Anti-biofilm Activity onFrontiers in microbiology · 2017Article
- Investigation ofFrontiers in microbiology · 2017Article
- Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children.Journal of fungi (Basel, Switzerland) · 2016Review
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4 authors.
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Abstract
backgroundCandida parapsilosis constitutes a common Candida spp. isolated in children with candidemia. Few data exist on risk factors and outcome of candidemia caused by C. parapsilosis in pediatric patients.
methodsWe conducted a retrospective analysis of demographic data, clinical features, therapeutic procedures and outcomes associated with Candida bloodstream infections (BSIs) that occurred at the Children's Hospital of Philadelphia between 1997 and 2009.
resultsAmong 406 Candida BSIs, Candida albicans accounted for 198 (49%), C. parapsilosis for 99 (24%) and all other species for 109 (27%) episodes. There was no consistent change in the proportion of C. parapsilosis BSIs during the study. C. parapsilosis BSI was more frequent than non-parapsilosis Candida spp. at age ≤2 years as compared with older patients (62% versus 50%, odds ratio = 1.24, 95% confidence interval: 1.03-1.51, P = 0.038). Patients with C. parapsilosis were more likely to be mechanically ventilated within 48 hours of BSI (odds ratio = 1.38, 95% confidence interval: 1.01-1.85, P = 0.047). Presence of a urinary catheter a week before infection was a protective factor for developing candidemia due to C. parapsilosis spp. (P = 0.003). No significant differences were found between the 2 groups in the presence of central intravascular catheters, comorbidities and clinical or surgical procedures, previous administration of immunosuppressive or antifungal agents and mortality.
conclusionsC. parapsilosis is the second most frequent cause of candidemia after C. albicans. Although it is more frequent at the age of ≤2 years and is more likely associated with mechanical ventilation than other Candida spp., mortality does not significantly differ between those with and without C. parapsilosis candidemia.
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