ArticleThe Pediatric infectious disease journal2012
Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Role of intestinal mucosal integrity in HIV transmission to infants through breast-feeding: the BAN study.The Journal of infectious diseases · 2013Trial
- Plasma galectin-9 relates to cognitive performance and inflammation among adolescents with vertically acquired HIV.AIDS (London, England) · 2024Article
- Article
- Altered Intestinal Permeability and Fungal Translocation in Ugandan Children With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.Neurobiology of disease · 2019Article
- Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019Review
- Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.The Journal of infectious diseases · 2019Article
- Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment.Frontiers in immunology · 2019Review
- High Abundance of genus Prevotella in the gut of perinatally HIV-infected children is associated with IP-10 levels despite therapy.Scientific reports · 2018Article
- Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.The Journal of infectious diseases · 2017Article
- Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation.Neuropharmacology · 2017Article
- Immune activation despite preserved CD4 T cells in perinatally HIV-infected children and adolescents.PloS one · 2017Article
- Impact of HIV Infection and Anti-Retroviral Therapy on the Immune Profile of and Microbial Translocation in HIV-Infected Children in Vietnam.International journal of molecular sciences · 2016Article
- Immune activation and paediatric HIV-1 disease outcome.Current opinion in HIV and AIDS · 2016Review
- New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression.Journal of immunology research · 2015Review
- Immune activation is associated with increased gut microbial translocation in treatment-naive, HIV-infected children in a resource-limited setting.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Article
- Immunity to HIV in Early Life.Frontiers in immunology · 2014Review
- Short communication: Evidence that microbial translocation occurs in HIV-infected children in the United Kingdom.AIDS research and human retroviruses · 2013Article
- Combination antiretroviral therapy with raltegravir leads to rapid immunologic reconstitution in treatment-naive patients with chronic HIV infection.The Journal of infectious diseases · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundGut microbial translocation (MT) is considered a major cause of immune activation (IA) and failure of immune reconstitution in HIV infection. This study investigated the relationship of virus replication, IA, CD4 counts and MT in HIV-infected children.
methodsLipopolysaccharide, bacterial 16S ribosomal DNA (16SrDNA) and soluble CD14 (sCD14) levels were determined in prospectively collected, stored plasma samples from the Pediatric AIDS Clinical Trials Group Protocol P338, a 48-week study initiated in 1997 to compare efficacy of dual nucleosides with a ritonavir-containing regimen. Results of MT were correlated with study data for T cell IA, plasma viral load and CD4 counts in 85 HIV-infected children (ages 2-17 years) designated as virologic responders or virologic failures (VF) at week 44 based on a cutoff of 400 HIV RNA copies/mL.
resultsLevels of plasma lipopolysaccharide, 16SrDNA and sCD14 were increased in comparison with HIV-uninfected controls and did not decrease at week 44 even in virologic responders. T cell IA was correlated with viral load and sCD14 at entry and with 16SrDNA and sCD14 at week 44 in total patients and in the VF group. Changes in 16SrDNA correlated with changes in IA and negatively with changes in CD4 counts. 16SrDNA was correlated with sCD14 but not with lipopolysaccharide.
conclusionsMT persists after 44 weeks of antiretroviral therapy in VS and VF patients. In VF, 16SrDNA exhibited relationships to monocyte and T cell IA and CD4 counts but not with viral load, suggesting a dominant role for MT in disease pathogenesis in HIV-infected children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.