ArticleGenome research2012
Rapid coastal spread of First Americans: novel insights from South America's Southern Cone mitochondrial genomes.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.Translational psychiatry · 2019Pooled it
- Maternal lineage diversity based on mitochondrial DNA in a population sample from Mexico City.Molecular biology reports · 2025Article
- Climate influence on the early human occupation of South America during the late Pleistocene.Nature communications · 2025Article
- Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment.Scientific reports · 2024Article
- The Genomic and Cultural Diversity of the Inka Qhapaq Hucha Ceremony in Chile and Argentina.Genome biology and evolution · 2024Article
- Population Histories and Genomic Diversity of South American Natives.Molecular biology and evolution · 2022Article
- A genomic perspective on South American human history.Genetics and molecular biology · 2022Article
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- Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America.iScience · 2021Article
- Fine-Tuning Phylogenetic Alignment and Haplogrouping of mtDNA Sequences.International journal of molecular sciences · 2021Article
- Long-distance dispersal of the beach strawberry, Fragaria chiloensis, from North America to Chile and Hawaii.Annals of botany · 2021Article
- Indigenous Ancestry and Admixture in the Uruguayan Population.Frontiers in genetics · 2021Article
- Exome Sequencing of Native Populations From the Amazon Reveals Patterns on the Peopling of South America.Frontiers in genetics · 2020Article
- Rapid radiation of humans in South America after the last glacial maximum: A radiocarbon-based study.PloS one · 2020Article
- The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations.Cell host & microbe · 2019Article
- Cultural Innovations Influence Patterns of Genetic Diversity in Northwestern Amazonia.Molecular biology and evolution · 2018Article
- Selecting among Alternative Scenarios of Human Evolution by Simulated Genetic Gradients.Genes · 2018Review
- Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 5 countries.
Funding
Abstract
It is now widely agreed that the Native American founders originated from a Beringian source population ~15-18 thousand years ago (kya) and rapidly populated all of the New World, probably mainly following the Pacific coastal route. However, details about the migration into the Americas and the routes pursued on the continent still remain unresolved, despite numerous genetic, archaeological, and linguistic investigations. To examine the pioneering peopling phase of the South American continent, we screened literature and mtDNA databases and identified two novel mitochondrial DNA (mtDNA) clades, here named D1g and D1j, within the pan-American haplogroup D1. They both show overall rare occurrences but local high frequencies, and are essentially restricted to populations from the Southern Cone of South America (Chile and Argentina). We selected and completely sequenced 43 D1g and D1j mtDNA genomes applying highest quality standards. Molecular and phylogeographic analyses revealed extensive variation within each of the two clades and possibly distinct dispersal patterns. Their age estimates agree with the dating of the earliest archaeological sites in South America and indicate that the Paleo-Indian spread along the entire longitude of the American double continent might have taken even <2000 yr. This study confirms that major sampling and sequencing efforts are mandatory for uncovering all of the most basal variation in the Native American mtDNA haplogroups and for clarification of Paleo-Indian migrations, by targeting, if possible, both the general mixed population of national states and autochthonous Native American groups, especially in South America.
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Registered trials
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