ArticleBMC plant biology2012
Functional alleles of the flowering time regulator FRIGIDA in the Brassica oleracea genome.
Article in BMC plant biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- A functional FRIa variant drives turnip adaptation to the Qinghai-Xizang Plateau.Molecular horticulture · 2026Article
- Role ofInternational journal of molecular sciences · 2025Article
- Molecular Evaluation of the Effects ofGenes · 2024Article
- Brassinosteroid Signaling Downstream Suppressor BIN2 Interacts with SLFRIGIDA-LIKE to Induce Early Flowering in Tomato.International journal of molecular sciences · 2022Article
- Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification.BMC biology · 2021Article
- Article
- Genome Triplication Leads to Transcriptional Divergence ofFrontiers in plant science · 2020Review
- The vernalisation regulator FLOWERING LOCUS C is differentially expressed in biennial and annual Brassica napus.Scientific reports · 2019Article
- The role of FRIGIDA and FLOWERING LOCUS C genes in flowering time of Brassica rapa leafy vegetables.Scientific reports · 2019Article
- Translating Flowering Time From Arabidopsis thaliana to Brassicaceae and Asteraceae Crop Species.Plants (Basel, Switzerland) · 2018Review
- Genome-Wide Identification of Flowering-Time Genes inInternational journal of molecular sciences · 2018Article
- Highly preserved roles of Brassica MIR172 in polyploid Brassicas: ectopic expression of variants of Brassica MIR172 accelerates floral transition.Molecular genetics and genomics : MGG · 2018Article
- Sequence variation and functional analysis of a FRIGIDA orthologue (BnaA3.FRI) in Brassica napus.BMC plant biology · 2018Article
- Nucleotide polymorphism affecting FLC expression underpins heading date variation in horticultural brassicas.The Plant journal : for cell and molecular biology · 2016Article
- Quantitative trait loci controlling leaf appearance and curd initiation of cauliflower in relation to temperature.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Natural history collections as windows on evolutionary processes.Molecular ecology · 2016Review
- Genome-wide gene expression perturbation induced by loss of C2 chromosome in allotetraploid Brassica napus L.Frontiers in plant science · 2015Article
- Crop epigenetics and the molecular hardware of genotype × environment interactions.Frontiers in plant science · 2015Review
- Genetic variation of temperature-regulated curd induction in cauliflower: elucidation of floral transition by genome-wide association mapping and gene expression analysis.Frontiers in plant science · 2015Article
- The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development.Journal of experimental botany · 2015Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPlants adopt different reproductive strategies as an adaptation to growth in a range of climates. In Arabidopsis thaliana FRIGIDA (FRI) confers a vernalization requirement and thus winter annual habit by increasing the expression of the MADS box transcriptional repressor FLOWERING LOCUS C (FLC). Variation at FRI plays a major role in A. thaliana life history strategy, as independent loss-of-function alleles that result in a rapid-cycling habit in different accessions, appear to have evolved many times. The aim of this study was to identify and characterize orthologues of FRI in Brassica oleracea.
resultsWe describe the characterization of FRI from Brassica oleracea and identify the two B. oleracea FRI orthologues (BolC.FRI.a and BolC.FRI.b). These show extensive amino acid conservation in the central and C-terminal regions to FRI from other Brassicaceae, including A. thaliana, but have a diverged N-terminus. The genes map to two of the three regions of B. oleracea chromosomes syntenic to part of A. thaliana chromosome 5 suggesting that one of the FRI copies has been lost since the ancient triplication event that formed the B. oleracea genome. This genomic position is not syntenic with FRI in A. thaliana and comparative analysis revealed a recombination event within the A. thaliana FRI promoter. This relocated A. thaliana FRI to chromosome 4, very close to the nucleolar organizer region, leaving a fragment of FRI in the syntenic location on A. thaliana chromosome 5. Our data show this rearrangement occurred after the divergence from A. lyrata. We explored the allelic variation at BolC.FRI.a within cultivated B. oleracea germplasm and identified two major alleles, which appear equally functional both to each other and A. thaliana FRI, when expressed as fusions in A. thaliana.
conclusionsWe identify the two Brassica oleracea FRI genes, one of which we show through A. thaliana complementation experiments is functional, and show their genomic location is not syntenic with A. thaliana FRI due to an ancient recombination event. This has complicated previous association analyses of FRI with variation in life history strategy in the Brassica genus.
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