ArticleRespiratory research2012
Fractionated breath condensate sampling: H(2)O(2) concentrations of the alveolar fraction may be related to asthma control in children.
Article in Respiratory research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulmonary biomarkers in COPD exacerbations: a systematic review.Respiratory research · 2013Pooled it
- Chemiluminescent Measurement of Hydrogen Peroxide in the Exhaled Breath Condensate of Healthy and Asthmatic Adults.Analytical chemistry · 2020Article
- The influence of active and passive air humidification on exhaled breath condensate volume.ERJ open research · 2020Article
- Features of Oxidative and Nitrosative Metabolism in Lung Diseases.Oxidative medicine and cellular longevity · 2019Review
- Using the Inflammacheck Device to Measure the Level of Exhaled Breath Condensate Hydrogen Peroxide in Patients With Asthma and Chronic Obstructive Pulmonary Disease (The EXHALE Pilot Study): Protocol for a Cross-Sectional Feasibility Study.JMIR research protocols · 2018Article
- Measuring Airway Inflammation in Asthmatic Children.Frontiers in pediatrics · 2018Review
- Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation.European respiratory review : an official journal of the European Respiratory Society · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a chronic inflammatory disease of the airways but recent studies have shown that alveoli are also subject to pathophysiological changes. This study was undertaken to compare hydrogen peroxide (H(2)O(2)) concentrations in different parts of the lung using a new technique of fractioned breath condensate sampling.
methodsIn 52 children (9-17 years, 32 asthmatic patients, 20 controls) measurements of exhaled nitric oxide (FE(NO)), lung function, H(2)O(2) in exhaled breath condensate (EBC) and the asthma control test (ACT) were performed. Exhaled breath condensate was collected in two different fractions, representing mainly either the airways or the alveoli. H(2)O(2) was analysed in the airway and alveolar fractions and compared to clinical parameters.
resultsThe exhaled H(2)O(2) concentration was significantly higher in the airway fraction than in the alveolar fraction comparing each single pair (p = 0.003, 0.032 and 0.040 for the whole study group, the asthmatic group and the control group, respectively). Asthma control, measured by the asthma control test (ACT), correlated significantly with the H(2)O(2) concentrations in the alveolar fraction (r = 0.606, p = 0.004) but not with those in the airway fraction in the group of children above 12 years. FE(NO) values and lung function parameters did not correlate to the H(2)O(2) concentrations of each fraction.
conclusionThe new technique of fractionated H(2)O(2) measurement may differentiate H(2)O(2) concentrations in different parts of the lung in asthmatic and control children. H(2)O(2) concentrations of the alveolar fraction may be related to the asthma control test in children.
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