ArticleFEMS immunology and medical microbiology2012
Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro.
Article in FEMS immunology and medical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Antibiofilm and Immunomodulatory Effects of Cinnamaldehyde in Corneal Epithelial Infection Models: Ocular Treatments Approach.Pharmaceutics · 2025Article
- Murraya koenigii methanolic extract inhibits bacterial growth and biofilm of Staphylococcus aureus and Enterococcus faecalis.Scientific reports · 2025Article
- Extracellular adherence proteins reduce matrix porosity and enhanceInfection and immunity · 2025Article
- Matrix porosity is associated withbioRxiv : the preprint server for biology · 2024Article
- VBNC Cronobacter sakazakii survives in macrophages by resisting oxidative stress and evading recognition by macrophages.BMC microbiology · 2024Article
- Review
- Enterococcus faecalis: implications for host health.World journal of microbiology & biotechnology · 2024Review
- Genome-wide analysis of acid tolerance genes of Enterococcus faecalis with RNA-seq and Tn-seq.BMC genomics · 2024Article
- Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistantFrontiers in immunology · 2024Article
- A bibliography study of Shewanella oneidensis biofilm.FEMS microbiology ecology · 2023Article
- Virulence Mechanisms of Common Uropathogens and Their Intracellular Localisation within Urothelial Cells.Pathogens (Basel, Switzerland) · 2022Article
- Pectolinarin Inhibits the Bacterial Biofilm Formation and Thereby Reduces Bacterial Pathogenicity.Antibiotics (Basel, Switzerland) · 2022Article
- Sugarcoating it: Enterococcal polysaccharides as key modulators of host-pathogen interactions.PLoS pathogens · 2021Review
- Absence of Circadian Rhythm in Fecal Microbiota of Laying Hens under Common Light.Animals : an open access journal from MDPI · 2021Article
- Lipid-Polymer Hybrid Nanoparticles Enhance the Potency of Ampicillin againstACS infectious diseases · 2021Article
- Biofilm Produced In Vitro byMicroorganisms · 2020Article
- Enhancing the Immune Response of a Nicotine Vaccine with Synthetic Small "Non-Natural" Peptides.Molecules (Basel, Switzerland) · 2020Article
- Cytokine Levels in thePolish journal of microbiology · 2019Article
- Detailed Soluble Proteome Analyses of a Dairy-IsolatedFrontiers in nutrition · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Enterococcus faecalis is a commensal organism of the gastrointestinal tract but can also cause serious opportunistic infections. In addition to high levels of antibiotic resistance, the ability to form biofilms on abiotic surfaces and on in-dwelling devices within the host complicates treatment strategies and successful outcomes of antibiotic therapy. Despite rapid advances made in recent years in understanding the genomics and virulence of this organism, much remains to be learned regarding the host response to enterococcal infections. In this study, we investigated the interaction of RAW264.7 macrophages and JAWS II dendritic cells with biofilm and planktonic E. faecalis, in vitro. Specifically, we compared phagocytosis, intracellular survival, secretion of proinflammatory cytokines, and the activation and maturation of phagocytes. Our results revealed that both macrophages and dendritic cells phagocytize biofilm mode cells at levels equal to or better than their planktonic counterparts. Internalized biofilm bacteria showed relatively greater survival at 24 h in macrophages than in dendritic cells and led to slightly higher expression of phagocyte activation markers. Macrophages infected with biofilm cells also secreted lower levels of proinflammatory cytokines studied. Overall, these results suggest that biofilm E. faecalis may be better adapted to overcome host defenses in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.