ArticleJournal of natural products2012
The tandem of full spin analysis and qHNMR for the quality control of botanicals exemplified with Ginkgo biloba.
Article in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity.Nanomaterials (Basel, Switzerland) · 2022Article
- Absolute Quantification of Isoflavones in the Flowers ofPlants (Basel, Switzerland) · 2022Article
- Pharmacokinetic, Metabolism, and Metabolomic Strategies Provide Deep Insight Into the Underlying Mechanism ofFrontiers in nutrition · 2022Review
- Resolving EntangledMolecules (Basel, Switzerland) · 2021Article
- Quantum mechanical NMR full spin analysis in pharmaceutical identity testing and quality control.Journal of pharmaceutical and biomedical analysis · 2021Review
- Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides fromJournal of natural products · 2020Article
- Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach.Natural product reports · 2019Review
- Selective Depletion and Enrichment of Constituents in "Curcumin" and Other Curcuma longa Preparations.Journal of natural products · 2019Article
- Quantification of terpene trilactones in Ginkgo biloba with aJournal of natural medicines · 2018Article
- Stereochemistry of a Second Riolozane and Other Diterpenoids from Jatropha dioica.Journal of natural products · 2017Article
- Computer-assistedMagnetic resonance in chemistry : MRC · 2017Article
- QM-HiFSA-Aided Structure Determination of Succinilenes A-D, New Triene Polyols from a Marine-Derived Streptomyces sp.Marine drugs · 2017Article
- Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving.The Journal of organic chemistry · 2016Article
- Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency.The Journal of organic chemistry · 2015Article
- Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.Journal of natural products · 2015Article
- K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).Journal of natural products · 2014Article
- Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.Journal of natural products · 2014Article
- Essential parameters for structural analysis and dereplication by (1)H NMR spectroscopy.Journal of natural products · 2014Article
- Orthogonal analytical methods for botanical standardization: determination of green tea catechins by qNMR and LC-MS/MS.Journal of pharmaceutical and biomedical analysis · 2014Article
- 2D NMR barcoding and differential analysis of complex mixtures for chemical identification: the Actaea triterpenes.Analytical chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Botanical dietary supplements and herbal remedies are widely used for health promotion and disease prevention. Due to the high chemical complexity of these natural products, it is essential to develop new analytical strategies to guarantee their quality and consistency. In particular, the precise characterization of multiple botanical markers remains a challenge. This study demonstrates how a combination of computer-aided spectral analysis and 1D quantitative ¹H NMR spectroscopy (qHNMR) generates the analytical foundation for innovative means of simultaneously identifying and quantifying botanical markers in complex mixtures. First, comprehensive ¹H NMR profiles (fingerprints) of selected botanical markers were generated via ¹H iterative full spin analysis (HiFSA) with PERCH. Next, the ¹H fingerprints were used to assign specific ¹H resonances in the NMR spectra of reference materials, enriched fractions, and crude extracts of Ginkgo biloba leaves. These ¹H fingerprints were then used to verify the assignments by 2D NMR. Subsequently, a complete purity and composition assessment by means of 1D qHNMR was conducted. As its major strengths, this tandem approach enables the simultaneous quantification of multiple constituents without the need for identical reference materials, the semiquantitative determination of particular subclasses of components, and the detection of impurities and adulterants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.