ArticleJournal of cognitive neuroscience2012
Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory.
Article in Journal of cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Effect of Gender, Physical Activity and Stress-Related Hormones on Adolescent's Academic Achievements.International journal of environmental research and public health · 2020Article
- Alterations in serotonin transporter and body image-related cognition in anorexia nervosa.NeuroImage. Clinical · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- Brain-Derived Neurotrophic Factor (Val66Met) and Serotonin Transporter (5-HTTLPR) Polymorphisms Modulate Plasticity in Inhibitory Control Performance Over Time but Independent of Inhibitory Control Training.Frontiers in human neuroscience · 2016Article
- Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Allelic Variation of Risk for Anxiety Symptoms Moderates the Relation Between Adolescent Safety Behaviors and Social Anxiety Symptoms.Journal of psychopathology and behavioral assessment · 2015Article
- Article
- Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.The International journal of neuroscience · 2014Article
- Article
- Serotonin transporter gene moderates associations between mood, memory and hippocampal volume.Behavioural brain research · 2013Article
- Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study.Psychiatry journal · 2013Article
- Article
- 5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents.NeuroImage · 2012Article
Corrections and comments
- Retraction · 2015-08-01Error in Data · Falsification/Fabrication of Data · Investigation by ORI · Misconduct by Author · · David E Anderson has ORI finding of misconduct;
- Retracted
- Retracted
Authors and funding
3 authors.
Funding
Abstract
Working memory (WM) is a limited capacity system that permeates nearly all levels of cognition, ranging from perceptual awareness to intelligence. Through behavioral, electrophysiological, and neuroimaging work, substantial gains have been made in understanding this capacity-limited system. In the current work, we examined genetic contributions to the storage capacity of WM. Multiple studies have demonstrated a link between the serotonin transporter-linked polymorphic region (5-HTTLPR) and cognition, where better performance is observed in individuals possessing a copy of the short (s) variant of the polymorphism compared with individuals homozygous for the long (l) variant. We predicted the same profile in WM performance, such that estimated capacities of l/l carriers should be smaller than s/s and s/l carriers. To measure WM capacity, we implemented a change detection task, which requires observers to actively maintain the color and spatial location of briefly presented squares over a short retention interval. In line with our prediction, we observed similar WM performance between s/s and s/l groups, and these individuals performed better than the l/l group. We then discuss the distribution of the serotonin transporter system and parallels between WM and attention to provide insight into how variation in the 5-HTT polymorphism could lead to individual differences in the storage capacity of WM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.