ArticleThe journal of physical chemistry. B2012
The membrane environment can promote or suppress bistability in cell signaling networks.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
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- Bimodality in Ras signaling originates from processivity of the Ras activator SOS without deterministic bistability.Science advances · 2024Article
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- Endoplasmic reticulum network heterogeneity guides diffusive transport and kinetics.Biophysical journal · 2023Article
- Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.Cell reports · 2021Article
- Diffusive search and trajectories on tubular networks: a propagator approach.The European physical journal. E, Soft matter · 2021Article
- Speed limits of protein assembly with reversible membrane localization.The Journal of chemical physics · 2021Article
- Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry.Molecular biology of the cell · 2021Article
- The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions.Biophysical journal · 2019Article
- Mechanical feedback enables catch bonds to selectively stabilize scanning microvilli at T-cell surfaces.Molecular biology of the cell · 2019Article
- Receptor recharge time drastically reduces the number of captured particles.PLoS computational biology · 2018Article
- Cytosolic proteins can exploit membrane localization to trigger functional assembly.PLoS computational biology · 2018Article
- Including Rebinding Reactions in Well-Mixed Models of Distributive Biochemical Reactions.Biophysical journal · 2016Article
- Effect of Spatial Inhomogeneities on the Membrane Surface on Receptor Dimerization and Signal Initiation.Frontiers in cell and developmental biology · 2016Article
- The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Science signaling · 2015Article
- Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins.Methods in cell biology · 2015Article
- Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.The Journal of experimental medicine · 2014Article
- Stochastic transitions in a bistable reaction system on the membrane.Journal of the Royal Society, Interface · 2013Article
- Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.Science signaling · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Many key biochemical reactions that mediate signal transduction in cells occur at the cell membrane, yet how the two-dimensional membrane environment influences the collective behavior of signaling networks is poorly understood. We study models of two topologically different signaling pathways that exhibit bistability, examining the effects of reduced protein mobility and increased concentration at the membrane, as well as effects due to differences in spatiotemporal correlations between the membrane environment and three-dimensional cytoplasm. The two model networks represent the distributive enzymatic modification of a protein at multiple sites and the positive feedback-mediated activation of a protein. In both cases, we find that confining proteins to a membrane-like environment can markedly alter the emergent dynamics. For the distributive protein modification network, increased concentration promotes bistability through enhanced protein-protein binding, while lower mobility and membrane-enhanced spatiotemporal correlations suppress bistability. For the positive feedback-mediated activation network, confinement to a membrane environment enhances protein activation, which can induce bistability or stabilize a monostable, active state. Importantly, the influence of the membrane environment on signaling dynamics can be qualitatively different for signaling modules with different network topologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.