ArticleThe Biochemical journal2012
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Article in The Biochemical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
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- Involvement of interferon-tau in the induction of apoptotic, pyroptotic, and autophagic cell death-related signaling pathways in the bovine uterine endometrium during early pregnancy.The Journal of reproduction and development · 2018Article
- Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2018Review
- Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity.Science signaling · 2018Article
- Recent advances in understanding inhibitor of apoptosis proteins.F1000Research · 2018Review
- The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease.Frontiers in immunology · 2018Review
- Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.Immunology and cell biology · 2017Review
- Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.Journal of thrombosis and haemostasis : JTH · 2016Article
- A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.Mucosal immunology · 2016Article
- Response to Heard et al.The EMBO journal · 2015Article
- cIAP2 supports viability of mice lacking cIAP1 and XIAP.The EMBO journal · 2015Article
- Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.Immunity · 2015Article
- Revisiting caspases in sepsis.Cell death & disease · 2014Review
- Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.EMBO molecular medicine · 2013Article
- Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.International immunology · 2013Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
A recent study revealed that ES (embryonic stem) cell lines derived from the 129 murine strain carry an inactivating mutation within the caspase 11 gene (Casp4) locus [Kayagaki, Warming, Lamkanfi, Vande Walle, Louie, Dong, Newton, Qu, Liu, Heldens, Zhang, Lee, Roose-Girma and Dixit (2011) Nature 479, 117-121]. Thus, if 129 ES cells are used to target genes closely linked to caspase 11, the resulting mice might also carry the caspase 11 deficiency as a passenger mutation. In the present study, we examined the genetic loci of mice targeted for the closely linked c-IAP (cellular inhibitor of apoptosis) genes, which were generated in 129 ES cells, and found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11. Consequently, data obtained from these mice should be re-evaluated in this new context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.