ReviewAdvances in nutrition (Bethesda, Md.)2012
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role.
Review in Advances in nutrition (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04782037 (Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age), which is not on this map. Cited by 466 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age
Who cites it
466 citing papers in PubMed, 5 syntheses or guidelines pooled it, 975 citations in OpenAlex.
- A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Pooled it
- Pooled it
- Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.Epigenetics · 2024Pooled it
- Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review.Translational psychiatry · 2023Pooled it
- Effects of maternal folate and vitamin B12 on gestational diabetes mellitus: a dose-response meta-analysis of observational studies.European journal of clinical nutrition · 2022Pooled it
- Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial.Clinical epigenetics · 2026Trial
- Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals - a randomized intervention trial.Epigenetics · 2024Trial
- Pro-Carcinogenic Implications of Folic Acid Supplementation During Chemically Induced Cutaneous Squamous Cell Carcinoma in Mice.Journal of biochemical and molecular toxicology · 2026Article
- Maternal lifestyle risk factors and human embryonic morphologic development using 3D ultrasound: a population-based prospective cohort study.Human reproduction (Oxford, England) · 2026Article
- Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism.bioRxiv : the preprint server for biology · 2026Article
- Dietary folate, vitamin D, and inflammation modify associations between prenatal per- and polyfluoroalkyl substance (PFAS) exposures and fetal growth.Nutrition and health · 2026Article
- Translational Study of Using FOCM/TS Metabolites for Supporting Autism Spectrum Disorder Diagnosis.Annals of biomedical engineering · 2026Article
- Microbiome-Epigenome Interplay Impacts Microbial Symbiosis and Stress Adaptations in the Brown Planthopper (International journal of molecular sciences · 2026Article
- The Impact of Nutrition on DNA Methylation: Methodological Challenges in Understanding Cause and Effect.Nutrients · 2026Review
- Construction and validation of a folate metabolism-related gene signature for prognosis prediction, immune landscape characterization, and molecular subtyping in glioma.Cancer causes & control : CCC · 2026Article
- Bioactive folate attenuates valproic acid-induced NAFLD in female rats.BMC gastroenterology · 2026Article
- Smart sensing the spectrum: cutting-edge biosensor and biomarker approaches for early autism detection.Metabolic brain disease · 2026Review
- Article
- Nutrition Across the Life Course and Risk of Young-Onset Breast Cancer: Mechanisms, Evidence, and Prevention Opportunities.Nutrients · 2026Review
- Folic acid deficiency in cancer therapy: a review of chemotherapy-induced malabsorption and supportive care strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
406 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an epigenetic modification critical to normal genome regulation and development. The vitamin folate is a key source of the one carbon group used to methylate DNA. Because normal mammalian development is dependent on DNA methylation, there is enormous interest in assessing the potential for changes in folate intake to modulate DNA methylation both as a biomarker for folate status and as a mechanistic link to developmental disorders and chronic diseases including cancer. This review highlights the role of DNA methylation in normal genome function, how it can be altered, and the evidence of the role of folate/folic acid in these processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.